← Back to patent-cliff list
替尔泊肽
Tier B — Position earlyTirzepatide · all drugs expiring in 2036 →
礼来制药
Originator
2022
First approval
2036
Expiry (public)
$36.51B ▲
Peak sales
化学药
Type
Targets：GLP1R、GIPR
Brand：ZEPBOUND KwikPen、穆峰达、Mounjaro、Mounjaro KwikPen、Zepbound
Indications (approved)：阻塞性睡眠呼吸暂停综合征、肥胖症、超重、二型糖尿病
Regional status
US
批准上市
2022-05-13
EU
批准上市
2022-09-15
China
批准上市
2024-05-15
Japan
批准上市
2022-09-26
Synthetic routes & intermediates9 routes
Originator routes × 0Optimised (non-patent) × 9Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 18 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Tirzepatide-001 | 71989-33-8Available | Fmoc-O-tert-butyl-L-serine |
| Tirzepatide-002 | - | Resin bound O-tert-butyl-L-serinamide |
| Tirzepatide-003 | - | Resin bound L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-004 | - | Resin bound L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-005 | - | Resin bound O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-006 | - | Resin bound L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-007 | - | Resin bound L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-008 | - | Resin bound Gly-Pro-Pro-Pro-Ser(tBu)-NH |
| Tirzepatide-009 | - | Resin bound O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-010 | - | Resin bound L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-011 | - | Resin bound glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-012 | - | Resin bound N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-013 | - | Resin bound L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-014 | - | Resin bound L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-015 | - | Resin bound L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-016 | - | Resin bound 1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-017 | - | Resin bound N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-018 | - | Resin bound L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
OptimisedRoute 2Steps 9 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Tirzepatide-019 | - | Resin bound L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-020 | - | Resin bound L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-021 | - | Resin bound N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-022 | - | Resin bound N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-023 | - | Resin bound L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-024 | - | Resin bound L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-025 | - | Resin bound N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-026 | - | Resin bound 4-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl--N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-Isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-027 | - | Resin bound L-leucyl-4-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-018 | - | Resin bound L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
OptimisedRoute 3Steps 10 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Tirzepatide-028 | - | Resin bound L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-029 | - | Resin bound 2-methylalanyl-L-leucyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-Isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-030 | - | Resin bound O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-031 | - | Resin bound O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-032 | - | Resin bound O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-033 | - | Resin bound O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-034 | - | Resin bound O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-035 | - | Resin bound L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-036 | - | Resin bound O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-027 | - | Resin bound L-leucyl-4-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
OptimisedRoute 4Steps 6 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Tirzepatide-037 | - | Resin bound N-(tert-butoxycarbonyl)-O-tert-butyl-L-tyrosyl-2-methylalanyl-O-tert-butyl-L-alpha-glutamylglycyl-O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-038 | - | Resin bound 2-methylalanyl-5-O-tert-butyl-L-alpha-glutamylglycyl-3-O-tert-butyl-L-threonyl-L-phenylalanyl-3-O-tert-butyl-L-threonyl-3-O-tert-butyl-L-seryl-4-O-tert-butyl-L-alpha-aspartyl-4-O'-tert-butyl-L-tyrosyl-3-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-4-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-5-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-5-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
| Tirzepatide-036 | - | Resin bound O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-039 | - | Resin bound glycyl-3-O-tert-butyl-L-threonyl-L-phenylalanyl-3-O-tert-butyl-L-threonyl-3-O-tert-butyl-L-seryl-4-O-tert-butyl-L-alpha-aspartyl-4'-O-tert-butyl-L-tyrosyl-3-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-4-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-5-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-5-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
| Tirzepatide-040 | - | Resin bound 5-O-tert-butyl-L-alpha-glutamylglycyl-3-O-tert-butyl-L-threonyl-L-phenylalanyl-3-O-tert-butyl-L-threonyl-3-O-tert-butyl-L-seryl-4-O-tert-butyl-L-alpha-aspartyl-4'-O-tert-butyl-L-tyrosyl-3-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-4-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-5-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-5-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-N-[(2,4-dimethoxyphenyl)methyl]glycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
OptimisedRoute 5Steps 13 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Tirzepatide-041 | - | Resin bound Glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-042 | - | Resin bound L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-043 | - | Resin bound L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-044 | - | Resin bound L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-045 | - | Resin bound L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-046 | - | Resin bound 1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-047 | - | Resin bound N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-048 | - | Resin bound L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-049 | - | Resin bound L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-050 | - | Resin bound N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-051 | - | Resin bound N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-052 | - | Resin bound N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-053 | - | Resin bound N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-Glycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-019 | - | Resin bound L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-020 | - | Resin bound L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-010 | - | Resin bound L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-011 | - | Resin bound glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-012 | - | Resin bound glycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-013 | - | Resin bound L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-018 | - | Resin bound L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-014 | - | Resin bound L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-015 | - | Resin bound L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-016 | - | Resin bound 1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-017 | - | Resin bound N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
OptimisedRoute 6Steps 10 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Tirzepatide-054 | - | Resin bound L-Alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-055 | - | Resin bound L-Alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-056 | - | Resin bound 2-Methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-057 | - | Resin bound 2-Methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-058 | - | Resin bound L-Isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-059 | - | Resin bound L-Isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-060 | - | Resin bound N6-(tert-Butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-061 | - | Resin bound N6-(tert-Butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-062 | - | Resin bound O-tert-Butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-063 | - | Resin bound O-tert-Butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-064 | - | Resin bound L-Leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-065 | - | Resin bound L-Leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-066 | - | Resin bound L-Isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-067 | - | Resin bound L-Isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-068 | - | Resin bound O-tert-Butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-069 | - | Resin bound O-tert-Butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-070 | - | Resin bound O-tert-Butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-071 | - | Resin bound O-tert-Butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-052 | - | Resin bound N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-glycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-053 | - | Resin bound N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanyl-Glycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
OptimisedRoute 7Steps 8 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Tirzepatide-072 | - | Resin bound O-tert-Butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-073 | - | Resin bound O-tert-Butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-074 | - | O-tert-Butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-075 | - | Resin bound O-tert-Butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-076 | - | Resin bound O-tert-Butyl-L-alpha-glutamylglycyl-O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-077 | - | Resin bound O-tert-Butyl-L-alpha-glutamylglycyl-O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-078 | - | Resin bound O-tert-Butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-079 | - | Resin bound O-tert-Butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-080 | - | Resin bound L-Phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-081 | - | Resin bound L-Phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-082 | - | Resin bound O-tert-Butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-083 | - | Resin bound O-tert-Butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-084 | - | Resin bound Glycyl-O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-085 | - | Resin bound Glycyl-O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-070 | - | Resin bound O-tert-Butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-071 | - | Resin bound O-tert-Butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
OptimisedRoute 8Steps 3 · Total yield 23.8g(Tirzepatide)
| Code | CAS No. | Intermediate |
|---|---|---|
| Tirzepatide-086 | - | Resin bound 2-Methylalanyl-5-O-tert-butyl-L-alpha-glutamylglycyl-3-O-tert-butyl-L-threonyl-L-phenylalanyl-3-O-tert-butyl-L-threonyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-3-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-4-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
| Tirzepatide-087 | - | Resin bound 2-Methylalanyl-5-O-tert-butyl-L-alpha-glutamylglycyl-3-O-tert-butyl-L-threonyl-L-phenylalanyl-3-O-tert-butyl-L-threonyl-3-O-tert-butyl-L-seryl-4-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-3-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-4-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-5-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
| Tirzepatide-088 | - | Resin bound O-tert-Butyl-L-tyrosyl-2-methylalanyl-5-O-tert-butyl-L-alpha-glutamylglycyl-3-O-tert-butyl-L-threonyl-L-phenylalanyl-3-O-tert-butyl-L-threonyl-3-O-tert-butyl-L-seryl-4-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-3-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-N-[(2S)-6-(tert-butyloxycarbonylamino)-1-oxohexan-2-yl]-4-O-tert-butyl-L-alpha-asparaginyl-L-Isoleucyl-L-alanyl-5-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-5-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
| Tirzepatide-089 | - | Resin bound O-tert-Butyl-L-tyrosyl-2-methylalanyl-5-O-tert-butyl-L-alpha-glutamylglycyl-3-O-tert-butyl-L-threonyl-L-phenylalanyl-3-O-tert-butyl-L-threonyl-3-O-tert-butyl-L-seryl-4-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-3-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-N-[(2S)-6-(tert-butyloxycarbonylamino)-1-oxohexan-2-yl]-4-O-tert-butyl-L-alpha-asparaginyl-L-Isoleucyl-L-alanyl-5-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-5-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
| Tirzepatide-076 | - | Resin bound O-tert-Butyl-L-alpha-glutamylglycyl-O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butyloxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-077 | - | Resin bound O-tert-Butyl-L-alpha-glutamylglycyl-O-tert-butyl-L-threonyl-L-phenylalanyl-O-tert-butyl-L-threonyl-O-tert-butyl-L-seryl-O-tert-butyl-L-alpha-aspartyl-O-tert-butyl-L-tyrosyl-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucyl-O-tert-butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(19-carboxynonadecanoyl)-D-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycyl-N-[(2,4-dimethoxyphenyl)methyl]glycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
OptimisedRoute 9Steps 4 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| Tirzepatide-090 | - | - |
| Tirzepatide-091 | - | - |
| Tirzepatide-092 | - | L-Phenylalanyl-L-valyl-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butoxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-O-tert-butyl-L-seryl-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-O-tert-butyl-L-serinamide |
| Tirzepatide-093 | - | (2S,5S,32S)-5-[[(5S,8S,11S,14S,17S)-11-[(2S)-Butan-2-yl]-8-[4-[(tert-butoxycarbonyl)amino]butyl]-5-(2-tert-butoxy-2-oxoethyl)-1-(9H-fluoren-9-yl)-14-methyl-3,6,9,12,15,18-hexaoxo-17-[3-oxo-3-[(triphenylmethyl)amino]propyl]-2-oxa-4,7,10,13,16-pentaazaoctadecan-18-yl]amino]-32-(tert-butoxycarbonyl)-2,55,55-trimethyl-4,11,20,29,34,53-hexaoxo-13,16,22,25,54-pentaoxa-3,10,19,28,33-pentaazahexapentacontan-1-oic acid |
| Tirzepatide-094 | - | 4-O-tert-Butyl-L-alpha-aspartyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-isoleucyl-L-alanyl-5-N-(triphenylmethyl)-L-glutaminyl-N6-(17-[[N-(20-tert-butoxy-20-oxoicosanoyl)-1-O-tert-butyl-L-gamma-glutamyl]amino]-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanan-1-oyl)-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-5-N-(triphenylmethyl)-L-glutaminyl-1-(tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-L-isoleucyl-L-alanylglycylglycyl-L-prolyl-3-O-tert-butyl-L-seryl-3-O-tert-butyl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-3-O-tert-butyl-L-serinamide |
| Tirzepatide-095 | - | N-(tert-Butoxycarbonyl)-4'-O-tert-butyl-L-tyrosyl-2-methylalanyl-5-O-tert-butyl-L-alpha-glutamylglycyl-3-O-tert-butyl-L-threonyl-L-phenylalanyl-3-O-tert-butyl-L-threonyl-3-O-tert-butyl-L-seryl-4-O-tert-butyl-L-alpha-aspartyl-4'-O-tert-butyl-L-tyrosyl-3-O-tert-butyl-L-seryl-L-isoleucyl-2-methylalanyl-L-leucine |
| Tirzepatide-096 | - | - |
Also available in our peptide catalogue
Frequently asked questions
What are the approved indications of Tirzepatide?
Approved indications include: 阻塞性睡眠呼吸暂停综合征, 肥胖症, 超重, 二型糖尿病.
When does the Tirzepatide patent expire?
Based on public sources, the Tirzepatide patent expires in 2036.
How many synthesis routes are recorded for Tirzepatide?
9 synthesis routes are recorded; the shortest is 3 steps with 23.8g(Tirzepatide) total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Tirzepatide intermediates?
1 intermediate CAS of Tirzepatide are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Tirzepatide intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24