Henagliflozin Proline
Tier C — Watch / tradeHenagliflozin Proline
Targets：SGLT2
Indications (approved)：Type 2 diabetes
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| HENAG-001 | 367-12-4 | 2-fluorophenol |
| HENAG-002 | 451-80-9 | 1-ethoxy-2-fluorobenzene |
| HENAG-003 | 21900-52-7 | 5-bromo-2-chlorobenzoyl chloride |
| HENAG-004 | 1358580-28-5 | (5-bromo-2-chlorophenyl)(4-ethoxy-3-fluorophenyl)methanone |
| HENAG-005 | 1358580-30-9 | (5-bromo-2-chlorophenyl)(4-ethoxy-3-fluorophenyl)methanol |
| HENAG-006 | 898538-31-3 | 4-bromo-1-chloro-2-(4-ethoxy-3-fluorobenzyl)benzene |
| HENAG-007 | 32384-65-9Available | (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one |
| HENAG-008 | 1358580-34-3 | (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol |
| HENAG-009 | 1358580-38-7 | (2S,3R,4S,5S,6R)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol |
| HENAG-010 | 1358580-41-2 | tert-butyldimethyl(((2R,3R,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-6-methoxytetrahydro-2H-pyran-2-yl)methoxy)silane |
| HENAG-011 | 1358580-43-4 | ((2R,3R,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-6-methoxytetrahydro-2H-pyran-2-yl)methanol |
| HENAG-012 | 1358580-46-7 | (2S,3S,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-6-methoxytetrahydro-2H-pyran-2-carbaldehyde |
| HENAG-013 | 1358580-49-0 | (2S,3S,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-2-carbaldehyde |
| HENAG-014 | 1358580-50-3 | ((3S,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-6-methoxytetrahydro-2H-pyran-2,2-diyl)dimethanol |
| HENAG-015 | 1358580-51-4 | ((1R,2S,3S,4R,5R)-2,3,4-tris(benzyloxy)-5-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-6,8-dioxabicyclo[3.2.1]octan-1-yl)methanol |
| Henagliflozein | - | (1R,2S,3S,4R,5R)-5-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol |
Frequently asked questions
What are the approved indications of Henagliflozin Proline?
Approved indications include: Type 2 diabetes.
When does the Henagliflozin Proline patent expire?
No public expiry year is available for Henagliflozin Proline yet; this page updates once verified.
How many synthesis routes are recorded for Henagliflozin Proline?
1 synthesis routes are recorded; the shortest is 13 steps with 420 mg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Henagliflozin Proline intermediates?
1 intermediate CAS of Henagliflozin Proline are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Henagliflozin Proline intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-27