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CAS 1358580-34-3
(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
Codes: HENAG-008
Application context (from source-drug indications)
Type 2 diabetesHenagliflozin ProlineDiastolic heart failureHenagliflozin ProlineNon-alcoholic steatohepatitisHenagliflozin ProlineKidney diseaseHenagliflozin ProlineDiabetesHenagliflozin ProlineHepatic function declineHenagliflozin Proline
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Henagliflozin Proline | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-fluorophenol→1-ethoxy-2-fluorobenzene→5-bromo-2-chlorobenzoyl chloride→(5-bromo-2-chlorophenyl)(4-ethoxy-3-fluorophenyl)methanone→(5-bromo-2-chlorophenyl)(4-ethoxy-3-fluorophenyl)methanol→4-bromo-1-chloro-2-(4-ethoxy-3-fluorobenzyl)benzene→(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one→(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol→(2S,3R,4S,5S,6R)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol→tert-butyldimethyl(((2R,3R,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-6-methoxytetrahydro-2H-pyran-2-yl)methoxy)silane→((2R,3R,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-6-methoxytetrahydro-2H-pyran-2-yl)methanol→(2S,3S,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-6-methoxytetrahydro-2H-pyran-2-carbaldehyde→(2S,3S,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-2-carbaldehyde→((3S,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-6-methoxytetrahydro-2H-pyran-2,2-diyl)dimethanol→((1R,2S,3S,4R,5R)-2,3,4-tris(benzyloxy)-5-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-6,8-dioxabicyclo[3.2.1]octan-1-yl)methanol→(1R,2S,3S,4R,5R)-5-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
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