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Ephedrine Sulfate

Avadel Legacy Pharmaceuticals Llc
Originator
2016
First approval
-
Expiry (public)
$0.02B ▲
Peak sales
化学药
Type

Targets:β-adrenoceptors、α-adrenoceptors

Brand:Isofedrol、Corphedra、Akovaz

Indications (approved):低血压

Regional status

US
批准上市
2016-04-29
EU
-
China
-
Japan
-

Synthetic routes & intermediates4 routes

Originator routes × 0Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 6 · Total yield /
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
Ephedrine Sulfate-00171-43-2Benzene
Ephedrine Sulfate-0027623-09-82-Chloropropanoyl chloride
Ephedrine Sulfate-0036084-17-92-Chloro-1-phenylpropan-1-one
Ephedrine Sulfate-0042114-00-3alpha-Bromopropiophenone
Ephedrine Sulfate-00574-89-5Methylamine
Ephedrine Sulfate-0065650-44-22-(Methylamino)-1-phenylpropan-1-one
Ephedrine Sulfate-007-(2R,3R)-2,3-Bis(benzoyloxy)butanedioic acid (2S)-2-(methylamino)-1-phenylpropan-1-one (1/2)
Ephedrine Sulfate-008-(2R,3R)-2,3-Bis(benzoyloxy)butanedioic acid (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol (1/2)
Ephedrine Sulfate-00950-98-6(-)-2(S)-(Methylamino)-1(R)-phenylpropan-1-ol hydrochloride
Ephedrine Sulfate-010299-42-3(-)-2(S)-(Methylamino)-1(R)-phenylpropan-1-ol
OptimisedRoute 2Steps 9 · Total yield /
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
Ephedrine Sulfate-0114407-36-7,104-54-1Cinnamyl alcohol
Ephedrine Sulfate-0121239893-18-5(±)-3-(Benzyloxy)-2-bromo-3-phenylpropan-1-ol
Ephedrine Sulfate-013-(±)-2-[(Benzyloxy)(phenyl)methyl]oxirane
Ephedrine Sulfate-0141819327-78-0(2R)-2-[(R)-(Benzyloxy)(phenyl)methyl]oxirane
Ephedrine Sulfate-0151819327-84-8(1R,2R)-1-(Benzyloxy)-1-phenylpropan-2-ol
Ephedrine Sulfate-0161819327-86-0(1R,2R)-1-(Benzyloxy)-1-phenylpropan-2-yl methanesulfonate
Ephedrine Sulfate-0171819327-88-2[(1R,2S)-2-Azido-1-(benzyloxy)propyl]benzene
Ephedrine Sulfate-0181819327-92-8Benzyl [(1R,2S)-1-(benzyloxy)-1-phenylpropan-2-yl]carbamate
Ephedrine Sulfate-01974-88-4AvailableMethyl iodide
Ephedrine Sulfate-0201819327-93-9Benzyl [(1R,2S)-1-(benzyloxy)-1-phenylpropan-2-yl]methylcarbamate
Ephedrine Sulfate-010299-42-3(-)-2(S)-(Methylamino)-1(R)-phenylpropan-1-ol
OptimisedRoute 3Steps 5 · Total yield /
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
Ephedrine Sulfate-02193-55-0Ethyl phenyl ketone
Ephedrine Sulfate-02217019-26-01-Phenylpropane-1,2-dione 2-oxime
Ephedrine Sulfate-023-(1R,2E)-2-(Hydroxyimino)-1-phenylpropan-1-ol
Ephedrine Sulfate-0241798-60-3(1R)-1-Hydroxy-1-phenylpropan-2-one
Ephedrine Sulfate-00574-89-5Methylamine
Ephedrine Sulfate-010299-42-3(-)-2(S)-(Methylamino)-1(R)-phenylpropan-1-ol
Ephedrine Sulfate-025100-52-7AvailableBenzaldehyde
Ephedrine Sulfate-026127-17-32-Oxopropionic acid
OptimisedRoute 4Steps 4 · Total yield 15g(Ephedrine Sulfate-031)
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
Ephedrine Sulfate-02193-55-0Propiophenone
Ephedrine Sulfate-02713171-64-7Dimethyl (2S,3S)-2,3-dihydroxysuccinate
Ephedrine Sulfate-0282639752-61-5Dimethyl (4S,5S)-2-ethyl-2-phenyl-1,3-dioxolane-4,5-dicarboxylate
Ephedrine Sulfate-0292639752-62-6Dimethyl (4S,5S)-2-[(1R)-1-bromoethyl]-2-phenyl-1,3-dioxolane-4,5-dicarboxylate
Ephedrine Sulfate-00574-89-5Methylamine
Ephedrine Sulfate-0302639549-30-5Dimethyl (4S,5S)-2-[(1S)-1-(methylamino)ethyl]-2-phenyl-1,3-dioxolane-4,5-dicarboxylate
Ephedrine Sulfate-031112117-24-5(2S)-2-(Methylamino)-1-phenylpropan-1-one

Frequently asked questions

What are the approved indications of Ephedrine Sulfate?

Approved indications include: 低血压.

When does the Ephedrine Sulfate patent expire?

No public expiry year is available for Ephedrine Sulfate yet; this page updates once verified.

How many synthesis routes are recorded for Ephedrine Sulfate?

4 synthesis routes are recorded; the shortest is 4 steps with 15g(Ephedrine Sulfate-031) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Ephedrine Sulfate intermediates?

2 intermediate CAS of Ephedrine Sulfate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Ephedrine Sulfate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24