CAS 74-88-4

Iodomethaneiodomethane-11CMethyl iodide

Codes：(I)270899-4-a、LACO-011、(XXXIV)638294-1-d、Ephedrine Sulfate-019、Desvenlafaxine-024

Application context (from source-drug indications)

重度抑郁症盐酸艾司氯胺酮自杀意念盐酸艾司氯胺酮抑郁症盐酸艾司氯胺酮麻醉盐酸艾司氯胺酮难治性抑郁症盐酸艾司氯胺酮疼痛盐酸艾司氯胺酮强直阵挛性癫痫拉考沙胺癫痫拉考沙胺癫痫部分性发作拉考沙胺癫痫发作拉考沙胺收缩性心力衰竭非奈利酮舒张期心力衰竭非奈利酮心脏衰竭非奈利酮慢性肾功能不全非奈利酮糖尿病肾病非奈利酮二型糖尿病非奈利酮低血压硫酸麻黄碱重度抑郁症地文拉法辛抑郁症地文拉法辛

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
盐酸艾司氯胺酮Esketamine Hydrochloride	Tier B — Position early	2029
拉考沙胺Lacosamide	Tier B — Position early	2028
非奈利酮Finerenone	Tier C — Watch / trade	2030
硫酸麻黄碱Ephedrine Sulfate	Tier C — Watch / trade	-
地文拉法辛Desvenlafaxine	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

盐酸艾司氯胺酮优化路线steps: 6total yield: /

Iodomethane→Chlorocyclopentane→1-Chloro-2-cyanobenzene→(2-Chlorophenyl)(cyclopentyl)methanone→2-Chlorobenzoyl chloride→Cyclopentene→(1-Bromocyclopentyl)(2-chlorophenyl) ketone→Aminomethane→1-[(E)-(2-Chlorophenyl)(methylimino)methyl]cyclopentan-1-ol hydrogen chloride→(±)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride→2-(2-Chlorophenyl)-2-(methylamino)cyclohexan-1-one→(2S)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone

拉考沙胺优化路线steps: 4total yield: 10.5 g

(tert-butoxycarbonyl)-D-serine→iodomethane-11C→N-(tert-butoxycarbonyl)-O-methyl-D-serine→O-methyl-D-serine→N-acetyl-O-methyl-D-serine

非奈利酮优化路线steps: 4total yield: /

2-Methoxy-4-cyanobenzaldehyde→3-Methoxy-4-methylbenzonitrile→3-Carboxyphenol→3-Hydroxybenzamide→3-Cyanophenol→Formaldehyde→4-Cyano-2-hydroxybenzaldehyde→Dimethoxysulfone→Iodomethane→2-Fluoro-4-cyanotoluene→Hydroxymethane→4-Bromo-3-methoxybenzamide→2-Methoxy-4-cyanobromobenzene

硫酸麻黄碱优化路线steps: 9total yield: /

Cinnamyl alcohol→(±)-3-(Benzyloxy)-2-bromo-3-phenylpropan-1-ol→(±)-2-[(Benzyloxy)(phenyl)methyl]oxirane→(2R)-2-[(R)-(Benzyloxy)(phenyl)methyl]oxirane→(1R,2R)-1-(Benzyloxy)-1-phenylpropan-2-ol→(1R,2R)-1-(Benzyloxy)-1-phenylpropan-2-yl methanesulfonate→[(1R,2S)-2-Azido-1-(benzyloxy)propyl]benzene→Benzyl [(1R,2S)-1-(benzyloxy)-1-phenylpropan-2-yl]carbamate→Methyl iodide→Benzyl [(1R,2S)-1-(benzyloxy)-1-phenylpropan-2-yl]methylcarbamate→(-)-2(S)-(Methylamino)-1(R)-phenylpropan-1-ol

地文拉法辛优化路线steps: 10total yield: 82.4g(Desvenlafaxine succinate (API))

2-(4-Hydroxyphenyl)acetonitrile→Cyclohexanone→(1-Hydroxycyclohexyl)(4-hydroxyphenyl)acetonitrile→4-[2-Amino-1-(1-hydroxycyclohexyl)ethyl]phenol→2-[4-(Oxan-2-yloxy)phenyl]acetonitrile→[4-(Benzyloxy)phenyl]acetonitrile→2-(1-Hydroxycyclohexyl)-2-[4-(oxan-2-yloxy)phenyl]acetonitrile→[4-(Benzyloxy)phenyl](1-hydroxycyclohexyl)acetonitrile→Iodomethane→4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	4-Bromo-2-methoxybenzaldehyde Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	4-AMino-5-Methylpyridin-2-ol Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	2-chloro-5-methylpyridin-4-amine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate Pharmaceutical Intermediates	询价	询价	询价	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.