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非那沙星
Tier C — Watch / tradeFinafloxacin
英国爱尔康公司
Originator
2014
First approval
-
Expiry (public)
No sales data
Peak sales
化学药
Type
Targets：Topoisomerase IV、Bacterial DNA gyrase
Brand：Xtoro
Indications (approved)：外耳炎
Regional status
US
批准上市
2014-12-17
EU
无进展
2008-09-01
China
-
Japan
-
Synthetic routes & intermediates2 routes
Originator routes × 1Optimised (non-patent) × 1Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 19 · Total yield 90 g
| Code | CAS No. | Intermediate |
|---|---|---|
| FINA-001 | 461-97-2 | 1-fluoro-3,5-dimethylbenzene |
| FINA-002 | 214774-61-5 | 2,4-dichloro-1-fluoro-3,5-dimethylbenzene |
| FINA-003 | 214774-60-4 | 2,4-dichloro-3-(dichloromethyl)-1-fluoro-5-(trichloromethyl)benzene |
| FINA-004 | 214774-58-0 | 2,4-dichloro-5-fluoro-3-formylbenzoic acid |
| FINA-005 | 214774-57-9 | (Z)-2,4-dichloro-5-fluoro-3-((hydroxyimino)methyl)benzoic acid |
| FINA-006 | 117528-59-3 | 2,4-dichloro-3-cyano-5-fluorobenzoyl chloride |
| FINA-007 | 924-99-2 | (Z)-ethyl 3-(dimethylamino)acrylate |
| FINA-008 | 1159908-25-4 | ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-(dimethylamino)acrylate |
| FINA-009 | 86483-52-5Available | cyclopropanamine |
| FINA-010 | 117528-63-9 | ethyl 3-(cyclopropylamino)-2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)acrylate |
| FINA-011 | 117528-64-0 | ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate |
| FINA-012 | 117528-65-1 | 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
| FINA-013 | 209401-69-4 | (4aS,7aS)-octahydropyrrolo[3,4-b][1,4]oxazine |
| FINA-014 | 821-11-4 | (E)-but-2-ene-1,4-diol |
| FINA-015 | 16851-72-2 | 1-tosyl-2,5-dihydro-1H-pyrrole |
| FINA-016 | 159555-66-5 | 3-tosyl-6-oxa-3-azabicyclo[3.1.0]hexane |
| FINA-017 | 141-43-5Available | 2-aminoethan-1-ol |
| FINA-018 | - | 4-((2-hydroxyethyl)amino)-1-tosylpyrrolidin-3-ol |
| FINA-019 | - | 2-(N-(4-hydroxy-1-tosylpyrrolidin-3-yl)-4-methylphenylsulfonamido)ethyl 4-methylbenzenesulfonate |
| FINA-020 | - | 4,6-ditosyloctahydropyrrolo[3,4-b][1,4]oxazine |
| FINA-021 | - | (4aS,7aS)-4,6-ditosyloctahydropyrrolo[3,4-b][1,4]oxazine |
OptimisedRoute 2Steps 24 · Total yield 21 g
| Code | CAS No. | Intermediate |
|---|---|---|
| FINA-006 | 117528-59-3 | 2,4-dichloro-3-cyano-5-fluorobenzoyl chloride |
| FINA-007 | 924-99-2 | (Z)-ethyl 3-(dimethylamino)acrylate |
| FINA-008 | 1159908-25-4 | ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-(dimethylamino)acrylate |
| FINA-009 | 86483-52-5Available | cyclopropanamine |
| FINA-010 | 117528-63-9 | ethyl 3-(cyclopropylamino)-2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)acrylate |
| FINA-011 | 117528-64-0 | ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate |
| FINA-014 | 821-11-4 | (E)-but-2-ene-1,4-diol |
| FINA-015 | 16851-72-2 | 1-tosyl-2,5-dihydro-1H-pyrrole |
| FINA-016 | 159555-66-5 | 3-tosyl-6-oxa-3-azabicyclo[3.1.0]hexane |
| FINA-022 | 1435-48-9 | 2,4-dichloro-1-fluorobenzene |
| FINA-023 | 704-10-9 | 1-(2,4-dichloro-5-fluorophenyl)ethanone |
| FINA-024 | 86522-89-6 | 2,4-dichloro-5-fluorobenzoic acid |
| FINA-025 | 106809-14-7 | 2,4-dichloro-5-fluoro-3-nitrobenzoic acid |
| FINA-026 | 1153285-12-1 | methyl 2,4-dichloro-5-fluoro-3-nitrobenzoate |
| FINA-027 | 1159908-24-3 | methyl 3-amino-2,4-dichloro-5-fluorobenzoate |
| FINA-028 | 220035-64-3 | methyl 2,4-dichloro-3-cyano-5-fluorobenzoate |
| FINA-029 | 117528-58-2 | 2,4-dichloro-3-cyano-5-fluorobenzoic acid |
| FINA-030 | 1159908-23-2 | (4aS,7aS)-tert-butyl hexahydropyrrolo[3,4-b][1,4]oxazine-4(4aH)-carboxylate |
| FINA-031 | 1159908-26-5 | (4aS,7aS)-tert-butyl 6-(8-cyano-1-cyclopropyl-3-(ethoxycarbonyl)-6-fluoro-4-oxo-1,4-dihydroquinolin-7-yl)hexahydropyrrolo[3,4-b][1,4]oxazine-4(4aH)-carboxylate |
| FINA-032 | 1159908-27-6 | 7-((4aS,7aS)-4-(tert-butoxycarbonyl)hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl)-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
| FINA-033 | 110-57-6 | (E)-1,4-dichlorobut-2-ene |
| FINA-034 | 3886-69-9Available | (R)-1-phenylethan-1-amine |
| FINA-035 | 1159908-18-5 | (3S,4S)-4-(((R)-1-phenylethyl)amino)-1-tosylpyrrolidin-3-ol |
| FINA-036 | 79-04-9Available | 2-chloroacetyl chloride |
| FINA-037 | 1159908-19-6 | 2-chloro-N-((3S,4S)-4-hydroxy-1-tosylpyrrolidin-3-yl)-N-((R)-1-phenylethyl)acetamide |
| FINA-038 | 1159908-20-9 | (4aS,7aS)-4-((R)-1-phenylethyl)-6-tosylhexahydropyrrolo[3,4-b][1,4]oxazin-3(2H)-one |
| FINA-039 | 1159908-21-0 | (4aS,7aS)-4-((R)-1-phenylethyl)-6-tosyloctahydropyrrolo[3,4-b][1,4]oxazine |
| FINA-040 | 159651-47-5 | (4aS,7aS)-6-tosyloctahydropyrrolo[3,4-b][1,4]oxazine |
| FINA-041 | 1159908-22-1 | (4aS,7aS)-tert-butyl 6-tosylhexahydropyrrolo[3,4-b][1,4]oxazine-4(4aH)-carboxylate |
Frequently asked questions
What are the approved indications of Finafloxacin?
Approved indications include: 外耳炎.
When does the Finafloxacin patent expire?
No public expiry year is available for Finafloxacin yet; this page updates once verified.
How many synthesis routes are recorded for Finafloxacin?
2 synthesis routes are recorded; the shortest is 19 steps with 90 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Finafloxacin intermediates?
4 intermediate CAS of Finafloxacin are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Finafloxacin intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24