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CAS 79-04-9
2-chloroacetyl chloride
Codes：RIVA-002、CARF-020、FINA-036、NINT-022、OLOD-006、BALI-018、VILD-002、RANO-001、SUNT-024
Application context (from source-drug indications)
肺栓塞利伐沙班中风利伐沙班先天性心脏缺损利伐沙班血栓形成利伐沙班静脉血栓栓塞利伐沙班冠状动脉疾病利伐沙班多发性骨髓瘤卡非佐米外耳炎非那沙星分泌性中耳炎非那沙星中耳炎非那沙星泌尿系统感染非那沙星肾盂肾炎非那沙星革兰氏阴性细菌感染非那沙星系统性硬化相关肺间质疾病乙磺酸尼达尼布特发性肺纤维化乙磺酸尼达尼布非小细胞肺癌乙磺酸尼达尼布肺纤维化乙磺酸尼达尼布间质性肺疾病乙磺酸尼达尼布遗传性出血性毛细血管扩张乙磺酸尼达尼布慢性阻塞性肺疾病盐酸奥达特罗慢性支气管炎盐酸奥达特罗气肿盐酸奥达特罗干眼症盐酸奥达特罗哮喘盐酸奥达特罗肝脏疾病盐酸奥达特罗荨麻疹比拉斯汀过敏性鼻炎比拉斯汀皮炎比拉斯汀瘙痒症比拉斯汀湿疹比拉斯汀变应性结膜炎比拉斯汀二型糖尿病维格列汀精神分裂症维格列汀血脂障碍维格列汀胰岛素抵抗维格列汀一型糖尿病维格列汀糖尿病维格列汀心绞痛雷诺嗪心肌梗塞雷诺嗪肌萎缩性侧索硬化雷诺嗪稳定型心绞痛雷诺嗪克罗恩病雷诺嗪炎症性肠疾病雷诺嗪胰腺神经内分泌肿瘤苹果酸舒尼替尼肾细胞癌苹果酸舒尼替尼胃肠道间质瘤苹果酸舒尼替尼骨肉瘤苹果酸舒尼替尼肉瘤苹果酸舒尼替尼淋巴瘤苹果酸舒尼替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 利伐沙班Rivaroxaban | Tier A — Act now | 2026 |
| 卡非佐米Carfilzomib | Tier B — Position early | 2029 |
| 非那沙星Finafloxacin | Tier C — Watch / trade | - |
| 乙磺酸尼达尼布Nintedanib Esylate | Tier B — Position early | - |
| 盐酸奥达特罗Olodaterol Hydrochloride | Tier C — Watch / trade | - |
| 比拉斯汀Bilastine | Tier C — Watch / trade | - |
| 维格列汀Vildagliptin | Tier B — Position early | - |
| 雷诺嗪Ranolazine | Tier C — Watch / trade | - |
| 苹果酸舒尼替尼Sunitinib Malate | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-aminoethan-1-ol→2-chloroacetyl chloride→2-(2-chloroacetamido)ethyl 2-chloroacetate→2-chloro-N-(2-hydroxyethyl)acetamide→morpholin-3-one→1-fluoro-4-nitrobenzene→4-(4-nitrophenyl)morpholin-3-one→4-(4-aminophenyl)morpholin-3-one→(S)-2-(oxiran-2-ylmethyl)isoindoline-1,3-dione→(R)-2-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione→(S)-2-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione→(S)-4-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one oxalate→5-chlorothiophene-2-carbonyl chloride
2-chloroacetyl chloride→4-(4-nitrophenyl)morpholin-3-one→4-(4-aminophenyl)morpholin-3-one→5-chlorothiophene-2-carbonyl chloride→2-(phenylamino)ethan-1-ol→4-phenylmorpholin-3-one→benzyl carbonochloridate→benzyl (4-(3-oxomorpholino)phenyl)carbamate→(R)-oxiran-2-ylmethyl butyrate→(R)-4-(4-(5-(hydroxymethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(R)-(2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl methanesulfonate→2-methylpropan-2-amine→(S)-4-(4-(5-((tert-butylamino)methyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(S)-N-(tert-butyl)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide
(tert-butoxycarbonyl)-L-leucine→(S)-2-((tert-butoxycarbonyl)amino)-4-phenylbutanoic acid→((S)-2-(2-morpholinoacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalanine→(S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-aminium 2,2,2-trifluoroacetate→tert-butyl (S)-(1-(methoxy(methyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate→tert-butyl (S)-(2,6-dimethyl-3-oxohept-1-en-4-yl)carbamate→tert-butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate→(S)-methyl 2-amino-3-phenylpropanoate→methyl (tert-butoxycarbonyl)-L-leucyl-L-phenylalaninate→(S)-1-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-aminium 2,2,2-trifluoroacetate→methyl ((S)-2-((tert-butoxycarbonyl)amino)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate→2-chloroacetyl chloride→methyl ((S)-2-(2-chloroacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate→morpholine→methyl ((S)-2-(2-morpholinoacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate→N,O-dimethylhydroxylamine hydrochloride→prop-1-en-2-ylmagnesium bromide
2,4-dichloro-3-cyano-5-fluorobenzoyl chloride→(Z)-ethyl 3-(dimethylamino)acrylate→ethyl 2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)-3-(dimethylamino)acrylate→cyclopropanamine→ethyl 3-(cyclopropylamino)-2-(2,4-dichloro-3-cyano-5-fluorobenzoyl)acrylate→ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate→(E)-but-2-ene-1,4-diol→1-tosyl-2,5-dihydro-1H-pyrrole→3-tosyl-6-oxa-3-azabicyclo[3.1.0]hexane→2,4-dichloro-1-fluorobenzene→1-(2,4-dichloro-5-fluorophenyl)ethanone→2,4-dichloro-5-fluorobenzoic acid→2,4-dichloro-5-fluoro-3-nitrobenzoic acid→methyl 2,4-dichloro-5-fluoro-3-nitrobenzoate→methyl 3-amino-2,4-dichloro-5-fluorobenzoate→methyl 2,4-dichloro-3-cyano-5-fluorobenzoate→2,4-dichloro-3-cyano-5-fluorobenzoic acid→(4aS,7aS)-tert-butyl hexahydropyrrolo[3,4-b][1,4]oxazine-4(4aH)-carboxylate→(4aS,7aS)-tert-butyl 6-(8-cyano-1-cyclopropyl-3-(ethoxycarbonyl)-6-fluoro-4-oxo-1,4-dihydroquinolin-7-yl)hexahydropyrrolo[3,4-b][1,4]oxazine-4(4aH)-carboxylate→7-((4aS,7aS)-4-(tert-butoxycarbonyl)hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl)-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid→(E)-1,4-dichlorobut-2-ene→(R)-1-phenylethan-1-amine→(3S,4S)-4-(((R)-1-phenylethyl)amino)-1-tosylpyrrolidin-3-ol→2-chloroacetyl chloride→2-chloro-N-((3S,4S)-4-hydroxy-1-tosylpyrrolidin-3-yl)-N-((R)-1-phenylethyl)acetamide→(4aS,7aS)-4-((R)-1-phenylethyl)-6-tosylhexahydropyrrolo[3,4-b][1,4]oxazin-3(2H)-one→(4aS,7aS)-4-((R)-1-phenylethyl)-6-tosyloctahydropyrrolo[3,4-b][1,4]oxazine→(4aS,7aS)-6-tosyloctahydropyrrolo[3,4-b][1,4]oxazine→(4aS,7aS)-tert-butyl 6-tosylhexahydropyrrolo[3,4-b][1,4]oxazine-4(4aH)-carboxylate
methyl 2-oxo-1,3-dihydroindole-6-carboxylate →(trimethoxymethyl)benzene→N-(4-aminophenyl)-2-(4-methylpiperazin-1-yl)acetamide→1-methylpiperazine→4-chloro-3-nitrobenzoic acid→methyl 4-chloro-3-nitrobenzoate→dimethyl malonate→dimethyl 2-(4-(methoxycarbonyl)-2-nitrophenyl)malonate→2-chloroacetic anhydride→methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate→(Z)-methyl 1-(2-chloroacetyl)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate→(Z)-methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate→ethanesulfonic acid→N-methyl-4-nitroaniline→2-chloroacetyl chloride→2-chloro-N-methyl-N-(4-nitrophenyl)acetamide
1-(2,5-dihydroxyphenyl)ethanone→(bromomethyl)benzene→1-(5-(benzyloxy)-2-hydroxyphenyl)ethanone→1-(5-(benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone→1-(3-amino-5-(benzyloxy)-2-hydroxyphenyl)ethanone→2-chloroacetyl chloride→8-acetyl-6-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one→6-(benzyloxy)-8-(2-ethoxy-2-hydroxyacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one→1-(4-methoxyphenyl)-2-methylpropan-2-amine→6-(benzyloxy)-8-(1-hydroxy-2-((1-(4-methoxyphenyl)-2-methylpropan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride→6-hydroxy-8-(1-hydroxy-2-((1-(4-methoxyphenyl)-2-methylpropan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride
1-(5-(benzyloxy)-2-hydroxyphenyl)ethanone→1-(5-(benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone→1-(3-amino-5-(benzyloxy)-2-hydroxyphenyl)ethanone→2-chloroacetyl chloride→8-acetyl-6-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one→1-(4-methoxyphenyl)-2-methylpropan-2-amine→6-(benzyloxy)-8-(2-chloroacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one→(R)-6-(benzyloxy)-8-(2-chloro-1-hydroxyethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one→(R)-6-(benzyloxy)-8-(oxiran-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one→(R)-6-(benzyloxy)-8-(1-hydroxy-2-((1-(4-methoxyphenyl)-2-methylpropan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
1-(2,5-dihydroxyphenyl)ethanone→(bromomethyl)benzene→1-(5-(benzyloxy)-2-hydroxyphenyl)ethanone→1-(5-(benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone→1-(3-amino-5-(benzyloxy)-2-hydroxyphenyl)ethanone→2-chloroacetyl chloride→8-acetyl-6-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one→1-(4-methoxyphenyl)-2-methylpropan-2-amine→6-(benzyloxy)-8-(1-hydroxy-2-((1-(4-methoxyphenyl)-2-methylpropan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride→(R)-6-(benzyloxy)-8-(oxiran-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one→6-(benzyloxy)-8-(2-bromoacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one→(R)-6-(benzyloxy)-8-(2-bromo-1-hydroxyethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole→ethyl 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoate→methyl 2-methyl-2-phenylpropanoate→2-chloroacetyl chloride→methyl 2-(4-(2-chloroacetyl)phenyl)-2-methylpropanoate→methyl 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)acetyl)phenyl)-2-methylpropanoate
(S)-pyrrolidine-2-carboxamide→2-chloroacetyl chloride→(S)-1-(2-chloroacetyl)pyrrolidine-2-carboxamide→N-(chloromethylene)-N-methylmethanaminium chloride→(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile→(1s,3r,5R,7S)-3-aminoadamantan-1-ol→(3s,5s,7s)-adamantan-1-amine→(1r,3s,5R,7S)-3-nitroadamantan-1-amine
2-chloroacetyl chloride→2,6-dimethylaniline→2-chloro-N-(2,6-dimethylphenyl)acetamide→2-((2-methoxyphenoxy)methyl)oxirane→2-methoxyphenol→2-(chloromethyl)oxirane→2,2'-azanediylbis(ethan-1-ol)→2-(bis(2-hydroxyethyl)amino)-N-(2,6-dimethylphenyl)acetamide→2-(bis(2-chloroethyl)amino)-N-(2,6-dimethylphenyl)acetamide→1-amino-3-(2-methoxyphenoxy)propan-2-ol
N1,N1-diethylethane-1,2-diamine→N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide→ethyl 3-oxobutanoate→ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate→ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate→5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid→diethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate→4-(ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid→diethyl (2-((4-fluoro-2-iodophenyl)amino)-2-oxoethyl)phosphonate→(Z)-N-(2-(diethylamino)ethyl)-5-(3-((4-fluoro-2-iodophenyl)amino)-3-oxoprop-1-en-1-yl)-2,4-dimethyl-1H-pyrrole-3-carboxamide→4-fluoro-2-iodoaniline→2-chloroacetyl chloride→2-chloro-N-(4-fluoro-2-iodophenyl)acetamide→triethyl phosphite
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 2-Piperidin-4-yl-1H-benzoimidazole Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 1-(2-Ethoxy-ethyl)-2-piperidin-4-yl-1H-benzimidazole Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 4-(2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)propan-2-yl)phenethyl 4-methylbenzenesulfonate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | CarbaMic acid, N-[(1S)-3-Methyl-1-[[(2R)-2-Methyl-2-oxiranyl]carbonyl]butyl]-, 1,1-diMethylethyl ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 1-Pentanone, 2-aMino-4-Methyl-1-[(2R)-2-Methyloxiranyl]-, (2S)-, trifluoroacetate (9CI) Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | (alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | (alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester mono(trifluoroacetate) Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | (alphaS)-alpha-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-L-phenylalanine methyl ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | Trimethyl orthobenzoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin -1-yl)acetamide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | Methyl 2-oxoindole-6-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | (3E)-2,3-Dihydro-3-(methoxyphenylmethylene) -2-oxo-1H-indole-6- carboxylic acid methyl ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 4-(4-Aminophenyl)morpholin -3-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | (S)-(+)-N-(2,3-Epoxypropyl)phthalimide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 5-Chlorothiophene-2-carboxylic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 5-Chlorothiophene-2-carbonyl chloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 2-[[(5S)-2-0x0-3-[4-(3-0xo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-1H-isoindole-1,3(2H)-dione Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 4-[4-[(5S)-5-(Aminomethyl)-2-0xo-3-oxazolidinyl]phenyl] -3-morpholinone hydrochloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 5-Fluoro-2-oxindole Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
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