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Calcipotriol

Tier C — Watch / trade

Calcipotriol

-
Originator
1990
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type

Targets：VDR

Brand：Daivonex, Divonex, Psorcutan, Dovonex, Sorilux

Indications (approved)：Psoriasis, Plaque psoriasis

Regional status

US
Approved
1993-12-29
EU
No progress
2015-11-23
China
Approved
2001-08-07
Japan
-

Synthetic routes & intermediates4 routes

Originator routes × 1Optimised (non-patent) × 3Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 15 · Total yield 483 mg (Calcipotriol)
CALCIP-00150-14-6CALCIP-00287680-65-7CALCIP-003170081-43-3CALCIP-00460123-29-7CALCIP-005112670-78-7CALCIP-006111594-58-2CALCIP-0072170464-36-3CALCIP-008—CALCIP-009—CALCIP-0107691-76-1CALCIP-011112849-17-9CALCIP-012112849-27-1CALCIP-013112849-27-1CALCIP-014765-43-5CALCIP-01569267-75-0CALCIP-016112849-15-7API · Calcipotriol
CodeCAS No.Intermediate
CALCIP-00150-14-6Available(S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol
CALCIP-00287680-65-7Available(6S)-1-((E)-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)methyl)-6-hydroxy-1,3,4,5,6,7-hexahydrobenzo[c]thiophene 2,2-dioxide
CALCIP-003170081-43-3Available2-((1R,3aS,7aR,E)-4-(((6S)-6-((tert-butyldimethylsilyl)oxy)-2,2-dioxido-1,3,4,5,6,7-hexahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal
CALCIP-00460123-29-7Availabletert-butyl(((S,E)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)dimethylsilane
CALCIP-005112670-78-7Available(1S,5R,E)-5-((tert-butyldimethylsilyl)oxy)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-2-methylenecyclohexanol
CALCIP-006111594-58-2Available(((1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane)
CALCIP-0072170464-36-3Available(4S,6R)-4,6-bis((tert-butyldimethylsilyl)oxy)-1-((E)-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)methyl)octahydrobenzo[c]thiophene 2,2-dioxide
CALCIP-008-(2S)-2-((1R,3aS,7aR,E)-4-(((4S,6R)-4,6-bis((tert-butyldimethylsilyl)oxy)-2,2-dioxidooctahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal
CALCIP-009-2-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)propanal
CALCIP-0107691-76-1Available1-cyclopropyl-2-(triphenylphosphoranylidene)ethanone
CALCIP-011112849-17-9Available(R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-one
CALCIP-012112849-27-1Available(1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol
CALCIP-013112849-27-1Available(1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol
CALCIP-014765-43-5Available1-cyclopropylethanone
CALCIP-01569267-75-0Available2-bromo-1-cyclopropylethanone
CALCIP-016112849-15-7Available-
OptimisedRoute 2Steps 3 · Total yield 89 mg (Calcipotriol)
CALCIP-017223538-02-1CALCIP-0181099618-83-3CALCIP-0191099618-85-5CALCIP-0201099618-87-7API · Calcipotriol
CodeCAS No.Intermediate
CALCIP-017223538-02-1Available(((1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-7a-methyl-1-((S)-1-(phenylsulfonyl)propan-2-yl)hexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane)
CALCIP-0181099618-83-3Available(S)-2-((tert-butyldiphenylsilyl)oxy)-2-cyclopropylacetaldehyde
CALCIP-0191099618-85-5Available(1S,4S)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-((tert-butyldiphenylsilyl)oxy)-1-cyclopropyl-3-(phenylsulfonyl)pentan-2-ol
CALCIP-0201099618-87-7Available(((1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5-((tert-butyldiphenylsilyl)oxy)-5-cyclopropylpent-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane)
OptimisedRoute 3Steps 12 · Total yield 22.6 g (Calcipotriol)
CALCIP-00150-14-6CALCIP-00287680-65-7CALCIP-003170081-43-3CALCIP-021170081-43-3CALCIP-0221329004-02-5CALCIP-023—CALCIP-024—CALCIP-025—CALCIP-0107691-76-1CALCIP-026—CALCIP-027—CALCIP-011112849-17-9CALCIP-012112849-27-1CALCIP-013112849-27-1API · Calcipotriol
CodeCAS No.Intermediate
CALCIP-00150-14-6Available(S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol
CALCIP-00287680-65-7Available(6S)-1-((E)-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)methyl)-6-hydroxy-1,3,4,5,6,7-hexahydrobenzo[c]thiophene 2,2-dioxide
CALCIP-003170081-43-3Available2-((1R,3aS,7aR,E)-4-(((6S)-6-((tert-butyldimethylsilyl)oxy)-2,2-dioxido-1,3,4,5,6,7-hexahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal
CALCIP-021170081-43-3Available2-((1R,3aS,7aR,E)-4-(((6S)-6-((tert-butyldimethylsilyl)oxy)-2,2-dioxido-1,3,4,5,6,7-hexahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal
CALCIP-0221329004-02-5Available2-((1R,3aS,7aR,E)-4-((E)-2-((S)-5-((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)propanal
CALCIP-023--
CALCIP-024--
CALCIP-025--
CALCIP-0107691-76-1Available1-cyclopropyl-2-(triphenylphosphoranylidene)ethanone
CALCIP-026--
CALCIP-027--
CALCIP-011112849-17-9Available(R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-one
CALCIP-012112849-27-1Available(1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol
CALCIP-013112849-27-1Available(1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol
OptimisedRoute 4Steps 9 · Total yield 198 mg (Calcipotriol)
CALCIP-0281342554-01-1CALCIP-029—CALCIP-030—CALCIP-0311971117-00-6CALCIP-0321971117-03-9CALCIP-033149-30-4CALCIP-0341971117-04-0CALCIP-0351971117-11-9CALCIP-036112828-13-4CALCIP-0381971117-18-6CALCIP-0371971117-18-6API · Calcipotriol
CodeCAS No.Intermediate
CALCIP-0281342554-01-1Available-
CALCIP-029--
CALCIP-030--
CALCIP-0311971117-00-6Available-
CALCIP-0321971117-03-9Available-
CALCIP-033149-30-4Available-
CALCIP-0341971117-04-0Available-
CALCIP-0351971117-11-9Available-
CALCIP-036112828-13-4Available-
CALCIP-0381971117-18-6Availablebenzyl ((1S,4R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-yl) carbonate
CALCIP-0371971117-18-6Availablebenzyl ((1S,4R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-yl) carbonate

Frequently asked questions

What are the approved indications of Calcipotriol?

Approved indications include: Psoriasis, Plaque psoriasis.

When does the Calcipotriol patent expire?

No public expiry year is available for Calcipotriol yet; this page updates once verified.

How many synthesis routes are recorded for Calcipotriol?

4 synthesis routes are recorded; the shortest is 3 steps with 89 mg (Calcipotriol) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Calcipotriol intermediates?

26 intermediate CAS of Calcipotriol are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Calcipotriol intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-27