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CAS 223538-02-1
(((1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-7a-methyl-1-((S)-1-(phenylsulfonyl)propan-2-yl)hexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane)
Codes: CALCIP-017
Application context (from source-drug indications)
Plaque psoriasisBetamethasone Dipropionate/CalcipotriolPsoriasisBetamethasone Dipropionate/CalcipotriolPhotoallergic dermatitisBetamethasone Dipropionate/CalcipotriolPhototoxic dermatitisBetamethasone Dipropionate/CalcipotriolPsoriasisCalcipotriolPlaque psoriasisCalcipotriol口腔白斑病CalcipotriolAlopeciaCalcipotriolLocalised sclerodermaCalcipotriolAcne vulgarisCalcipotriol
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Betamethasone Dipropionate/Calcipotriol | Tier C — Watch / trade | - |
| Calcipotriol | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(((1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-7a-methyl-1-((S)-1-(phenylsulfonyl)propan-2-yl)hexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane)→(S)-2-((tert-butyldiphenylsilyl)oxy)-2-cyclopropylacetaldehyde→(1S,4S)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-((tert-butyldiphenylsilyl)oxy)-1-cyclopropyl-3-(phenylsulfonyl)pentan-2-ol→(((1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5-((tert-butyldiphenylsilyl)oxy)-5-cyclopropylpent-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane)
(((1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-7a-methyl-1-((S)-1-(phenylsulfonyl)propan-2-yl)hexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane)→(S)-2-((tert-butyldiphenylsilyl)oxy)-2-cyclopropylacetaldehyde→(1S,4S)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-((tert-butyldiphenylsilyl)oxy)-1-cyclopropyl-3-(phenylsulfonyl)pentan-2-ol→(((1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5-((tert-butyldiphenylsilyl)oxy)-5-cyclopropylpent-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane)
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | (2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-2-penten-1-one Pharmaceutical Intermediates | On request | On request | On request | — |
| Unibest Taizhou GMP-like Site | Bis-TBDMS-trans-calcipotriol Pharmaceutical Intermediates | On request | On request | On request | — |
| Qualified Partner — East China API Works | (5E)-Calcipotriene Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.