Unibest 优贝德
← Back to patent-cliff list

罗替高汀

Tier C — Watch / trade

Rotigotine

比利时联合化工集团
Originator
2006
First approval
-
Expiry (public)
$0.5B ▲
Peak sales
化学药
Type

Targets：DRDs

Brand：Rotigotine CDS、Leganto、Neupro

Indications (approved)：不宁腿综合征、帕金森病

Regional status

US
批准上市
2007-05-09
EU
批准上市
2006-02-15
China
批准上市
2018-06-08
Japan
批准上市
2012-12-25

Synthetic routes & intermediates5 routes

Originator routes × 0Optimised (non-patent) × 5Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 9 · Total yield 119 g
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
ROTI-001575-44-0Availablenaphthalene-1,6-diol
ROTI-0023900-49-0Available1,6-dimethoxynaphthalene
ROTI-00332940-15-1Available5-methoxy-3,4-dihydronaphthalen-2(1H)-one
ROTI-0044018-91-1Available5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine
ROTI-00517199-29-0Available(S)-2-hydroxy-2-phenylacetic acid
ROTI-006439133-67-2Available(S)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine (S)-2-hydroxy-2-phenylacetate
ROTI-007105086-80-4Available(S)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine
ROTI-00840412-06-4Available2-(thiophen-2-yl)ethyl 4-methylbenzenesulfonate
ROTI-0091232344-35-2Available(S)-5-methoxy-N-(2-(thiophen-2-yl)ethyl)-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride
ROTI-01079-09-4Availablepropionic acid
ROTI-0111232344-37-4Available(S)-5-methoxy-N-propyl-N-(2-(thiophen-2-yl)ethyl)-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride
OptimisedRoute 2Steps 5 · Total yield /
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
ROTI-00840412-06-4Available2-(thiophen-2-yl)ethyl 4-methylbenzenesulfonate
ROTI-01258349-17-0Available5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride
ROTI-013123-38-6Availablepropionaldehyde
ROTI-0143899-07-8Available5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine
ROTI-01520312-36-1Available(S)-2-hydroxy-3-phenylpropanoic acid
ROTI-0161352917-67-9Available(S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine (S)-2-hydroxy-3-phenylpropanoate
ROTI-01793601-86-6Available(S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride
ROTI-018101470-23-9Available(S)-6-(propylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
OptimisedRoute 3Steps 9 · Total yield 143 mg
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
ROTI-00332940-15-1Available5-methoxy-3,4-dihydronaphthalen-2(1H)-one
ROTI-007105086-80-4Available(S)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine
ROTI-0191433830-35-3Available5-methoxy-2-((trimethylsilyl)oxy)-1,2,3,4-tetrahydronaphthalene-2-carbonitrile
ROTI-0202741-79-9Available2-hydroxy-5-methoxy-1,2,3,4-tetrahydronaphthalene-2-carbonitrile
ROTI-0211433830-39-7Available2-cyano-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl methanesulfonate
ROTI-0221551181-12-4Available5-methoxy-1,2,3,4-tetrahydronaphthalene-2-carbonitrile
ROTI-023146982-06-1Available5-methoxy-1,2,3,4-tetrahydronaphthalene-2-carbaldehyde
ROTI-024328553-19-1Available(S)-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)methanol
ROTI-025159304-63-9Available(S)-5-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid
ROTI-0261433831-41-4Availablebenzyl (S)-(5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)carbamate
OptimisedRoute 4Steps 9 · Total yield 128 mg
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
ROTI-00840412-06-4Available2-(thiophen-2-yl)ethyl 4-methylbenzenesulfonate
ROTI-018101470-23-9Available(S)-6-(propylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
ROTI-0272845-89-8Available1-chloro-3-methoxybenzene
ROTI-028110-00-9Availablefuran
ROTI-02965818-87-3Available5-methoxy-1,4-dihydro-1,4-epoxynaphthalene
ROTI-0302032-33-9AvailableN-benzylpropan-1-amine
ROTI-0311256260-95-3Available(1S,2S)-2-(benzyl(propyl)amino)-5-methoxy-1,2-dihydronaphthalen-1-ol
ROTI-0321256260-97-5Available(1S,2S)-2-(benzyl(propyl)amino)-5-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol
ROTI-0331256260-98-6Available(1S,2S)-5-methoxy-2-(propylamino)-1,2,3,4-tetrahydronaphthalen-1-ol
ROTI-0341256260-99-7Availabletert-butyl ((1S,2S)-1-hydroxy-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)carbamate
ROTI-0351256261-00-3Available(3aS,9bR)-6-methoxy-3-propyl-3a,4,5,9b-tetrahydronaphtho[2,1-d]oxazol-2(3H)-one
ROTI-036101403-24-1Available(S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine
OptimisedRoute 5Steps 4 · Total yield 79.8 g
Synthetic routes & intermediates Route 5
CodeCAS No.Intermediate
ROTI-0044018-91-1Available5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine
ROTI-007105086-80-4Available(S)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine
ROTI-036101403-24-1Available(S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine
ROTI-037106-94-5Available1-bromopropane
ROTI-03826478-16-0Available2-(2-bromoethyl)thiophene
ROTI-0391148154-91-9Available(S)-5-methoxy-N-propyl-N-(2-(thiophen-2-yl)ethyl)-1,2,3,4-tetrahydronaphthalen-2-amine

Frequently asked questions

What are the approved indications of Rotigotine?

Approved indications include: 不宁腿综合征, 帕金森病.

When does the Rotigotine patent expire?

No public expiry year is available for Rotigotine yet; this page updates once verified.

How many synthesis routes are recorded for Rotigotine?

5 synthesis routes are recorded; the shortest is 4 steps with 79.8 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Rotigotine intermediates?

39 intermediate CAS of Rotigotine are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Rotigotine intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24