CAS 106-94-5

1-bromopropane

Codes：TICA-044、ROTI-037

Application context (from source-drug indications)

中风替格瑞洛急性冠脉综合征替格瑞洛心肌梗塞替格瑞洛外周血管疾病替格瑞洛不宁腿综合征罗替高汀帕金森病罗替高汀物质相关性障碍罗替高汀药物相关的副作用和不良反应罗替高汀组织粘连罗替高汀术后疼痛罗替高汀

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
替格瑞洛Ticagrelor	Tier B — Position early	2029
罗替高汀Rotigotine	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

替格瑞洛优化路线steps: 5total yield: 192 mg

4,6-dichloro-2-(propylthio)pyrimidin-5-amine→diethyl 2-acetamidomalonate→thiourea→sodium 5-acetamido-4,6-dihydroxypyrimidine-2-thiolate→N-(4,6-dihydroxy-2-mercaptopyrimidin-5-yl)acetamide→1-bromopropane→N-(4,6-dihydroxy-2-(propylthio)pyrimidin-5-yl)acetamide→5-amino-2-(propylthio)pyrimidine-4,6-diol hydrochloride

罗替高汀优化路线steps: 4total yield: 79.8 g

5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine→(S)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine→(S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine→1-bromopropane→2-(2-bromoethyl)thiophene→(S)-5-methoxy-N-propyl-N-(2-(thiophen-2-yl)ethyl)-1,2,3,4-tetrahydronaphthalen-2-amine

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	5-Methoxy-2-tetralone Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	(S)-2-AMINO-5-METHOXYTETRALIN HYDROCHLORIDE Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	(S)-2-Amino-5-methoxytetralin Hydrochloride Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	(S)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine hydrochloride Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	(S)-2-Amino-5-methoxytetralin (S)-mandelate Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	4,6-Dichloro-2-(propylthio)pyrimidin -5-amine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro -3aH-cyclopenta[d][1,3]dioxol -4-yloxy)ethanol L-tataric acid Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminium(2R)hydroxy(phenyl)ethanoate Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[[5-aMino-6-chloro-2-(propylthio)-4-pyriMidinyl]aMino]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]- Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1) Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	2-[[(3aS,4R,6S,6aR)-4-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-6-yl]oxy]ethanol Pharmaceutical Intermediates	询价	询价	询价	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.