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达比加群酯甲磺酸盐

Tier B — Position early

Dabigatran Etexilate Mesylate

勃林格殷格翰
Originator
2008
First approval
-
Expiry (public)
$1.75B ▲
Peak sales
化学药
Type

Targets：PT

Brand：Pradaxa、Prazaxa、泰毕全、Rendix、Pradax

Indications (approved)：静脉血栓栓塞、栓塞、中风、缺血性卒中、肺栓塞、静脉血栓形成

Regional status

US
批准上市
2010-10-19
EU
批准上市
2008-03-17
China
批准上市
2013-02-22
Japan
批准上市
2011-01-21

Synthetic routes & intermediates7 routes

Originator routes × 1Optimised (non-patent) × 6Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 7 · Total yield 0.61g
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
DABI-00141263-74-5Available4-(methylamino)-3-nitrobenzoic acid
DABI-00282357-48-0Available4-(methylamino)-3-nitrobenzoyl chloride
DABI-003103041-38-9Availableethyl 3-(pyridin-2-ylamino)propanoate
DABI-004429659-01-8Availableethyl 3-(4-(methylamino)-3-nitro-N-(pyridin-2-yl)benzamido)propanoate
DABI-005212322-56-0Availableethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate
DABI-00642288-26-6Available2-((4-cyanophenyl)amino)acetic acid
DABI-007211915-84-3Availableethyl 3-(2-(((4-cyanophenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate
DABI-0081354727-65-3Availableethyl 3-(2-(((4-(ethoxy(imino)methyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate hydrochloride
DABI-009-ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate hydrochloride
DABI-0106092-54-2Availablehexyl carbonochloridate
OptimisedRoute 2Steps 3 · Total yield 13.6 g
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
DABI-003103041-38-9Availableethyl 3-(pyridin-2-ylamino)propanoate
DABI-004429659-01-8Availableethyl 3-(4-(methylamino)-3-nitro-N-(pyridin-2-yl)benzamido)propanoate
DABI-01196-99-1Available4-chloro-3-nitrobenzoic acid
DABI-01238818-50-7Available4-chloro-3-nitrobenzoyl chloride
DABI-0131620205-04-0Availableethyl 3-(4-chloro-3-nitro-N-(pyridin-2-yl)benzamido)propanoate
OptimisedRoute 3Steps 7 · Total yield 42 g
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
DABI-005212322-56-0Availableethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate
DABI-0106092-54-2Availablehexyl carbonochloridate
DABI-014873-74-5Available4-aminobenzonitrile
DABI-015-(Z)-4-amino-N'-hydroxybenzimidamide
DABI-016864680-71-7Available3-(4-aminophenyl)-1,2,4-oxadiazol-5(4H)-one
DABI-017105-36-2Availableethyl 2-bromoacetate
DABI-018872728-83-1Availableethyl (4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl)glycinate
DABI-019872728-82-0Available(4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl)glycine
DABI-020872728-84-2Availableethyl 3-(1-methyl-2-(((4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl)amino)methyl)-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate
DABI-021-ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate
OptimisedRoute 4Steps 3 · Total yield 13.8 g
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
DABI-005212322-56-0Availableethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate
DABI-0106092-54-2Availablehexyl carbonochloridate
DABI-022541-88-8Available2-chloroacetic anhydride
DABI-0231307233-94-8Availableethyl 3-(2-(chloromethyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate
DABI-0241307233-93-7Availablehexyl (E)-(amino(4-aminophenyl)methylene)carbamate hydrochloride
DABI-0252498-50-2Available4-aminobenzimidamide dihydrochloride
OptimisedRoute 5Steps 2 · Total yield 57.2 g
Synthetic routes & intermediates Route 5
CodeCAS No.Intermediate
DABI-005212322-56-0Availableethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate
DABI-0241307233-93-7Availablehexyl (E)-(amino(4-aminophenyl)methylene)carbamate hydrochloride
DABI-02613094-51-4Available2-bromoacetic anhydride
DABI-027-ethyl 3-(3-(2-bromoacetamido)-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate
OptimisedRoute 6Steps 9 · Total yield 44 g
Synthetic routes & intermediates Route 6
CodeCAS No.Intermediate
DABI-00141263-74-5Available4-(methylamino)-3-nitrobenzoic acid
DABI-00282357-48-0Available4-(methylamino)-3-nitrobenzoyl chloride
DABI-003103041-38-9Availableethyl 3-(pyridin-2-ylamino)propanoate
DABI-004429659-01-8Availableethyl 3-(4-(methylamino)-3-nitro-N-(pyridin-2-yl)benzamido)propanoate
DABI-005212322-56-0Availableethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate
DABI-00642288-26-6Available2-((4-cyanophenyl)amino)acetic acid
DABI-007211915-84-3Availableethyl 3-(2-(((4-cyanophenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate
DABI-0106092-54-2Availablehexyl carbonochloridate
DABI-01196-99-1Available4-chloro-3-nitrobenzoic acid
DABI-02874-11-3Available4-chlorobenzoic acid
DABI-029-ethyl 3-(2-(((4-(ethoxy(imino)methyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate
DABI-030-ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate oxalate
OptimisedRoute 7Steps 8 · Total yield 22 g
Synthetic routes & intermediates Route 7
CodeCAS No.Intermediate
DABI-005212322-56-0Availableethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate
DABI-0106092-54-2Availablehexyl carbonochloridate
DABI-017105-36-2Availableethyl 2-bromoacetate
DABI-031619-72-7Available4-nitrobenzonitrile
DABI-032-(Z)-N'-hydroxy-4-nitrobenzimidamide
DABI-03325283-96-9Available5-methyl-3-(4-nitrophenyl)-1,2,4-oxadiazole
DABI-03410185-68-9Available4-(5-methyl-1,2,4-oxadiazol-3-yl)aniline
DABI-035253796-85-9Availableethyl (4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)glycinate
DABI-036253796-86-0Available(4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)glycine
DABI-0371411034-23-5Availableethyl 3-(1-methyl-2-(((4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)amino)methyl)-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate
DABI-038872728-85-3Availableethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate 4-methylbenzenesulfonate

Frequently asked questions

What are the approved indications of Dabigatran Etexilate Mesylate?

Approved indications include: 静脉血栓栓塞, 栓塞, 中风, 缺血性卒中, 肺栓塞, 静脉血栓形成.

When does the Dabigatran Etexilate Mesylate patent expire?

No public expiry year is available for Dabigatran Etexilate Mesylate yet; this page updates once verified.

How many synthesis routes are recorded for Dabigatran Etexilate Mesylate?

7 synthesis routes are recorded; the shortest is 2 steps with 57.2 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Dabigatran Etexilate Mesylate intermediates?

31 intermediate CAS of Dabigatran Etexilate Mesylate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Dabigatran Etexilate Mesylate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24