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盐酸左米那普仑

Tier C — Watch / trade

Levomilnacipran Hydrochloride

Forest Laboratories Inc
Originator
2013
First approval
-
Expiry (public)
$0.01B ▲
Peak sales
化学药
Type

TargetsNET、SERT

BrandFetzima

Indications (approved)重度抑郁症

Regional status

US
批准上市
2013-07-25
EU
无进展
2012-07-01
China
临床三期
2024-10-17
Japan
-

Synthetic routes & intermediates4 routes

Originator routes × 1Optimised (non-patent) × 2Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 3 · Total yield /
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
LEVO-001-(1S)-ethyl 2-(aminomethyl)-1-phenylcyclopropanecarboxylate
LEVO-002810696-15-2(1S)-2-(aminomethyl)-1-phenylcyclopropanecarboxylic acid hydrochloride
LEVO-003-(1S)-2-(aminomethyl)-1-phenylcyclopropanecarbonyl chloride hydrochloride
OptimisedRoute 3Steps 2 · Total yield 10.95 kg (Levomilnacipran Hydrochloride)
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
LEVO-0131001017-62-4-
LEVO-014100-97-01,3,5,7-tetraazaadamantane
LEVO-015109001-33-41-(((1R,2S)-2-(diethylcarbamoyl)-2-phenylcyclopropyl)methyl)-1,3,5,7-tetraazaadamantan-1-ium bromide
OptimisedRoute 4Steps 11 · Total yield /
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
LEVO-00896847-53-9(1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one
LEVO-009172015-99-5-
LEVO-016107-18-6-
LEVO-017103-80-0-
LEVO-0181797-74-6-
LEVO-019145193-16-4-
LEVO-020174848-98-7-
LEVO-021106-95-6Available-
LEVO-022103-82-2-
LEVO-02321490-59-5-
LEVO-0241393058-97-3-
LEVO-0251644291-41-7-
LEVO-026403789-25-3-
ProcessRoute 2Steps 7 · Total yield 41 kg
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
LEVO-00451594-55-9(R)-2-(chloromethyl)oxirane
LEVO-005140-29-42-phenylacetonitrile
LEVO-0061535163-09-7(1S,2R)-2-(hydroxymethyl)-1-phenylcyclopropanecarbonitrile
LEVO-00796847-51-7(1S,2R)-2-(hydroxymethyl)-1-phenylcyclopropanecarboxylic acid
LEVO-00896847-53-9(1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one
LEVO-009172015-99-5(1S,2R)-N,N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropanecarboxamide
LEVO-0101237261-60-7(1S,2R)-2-(chloromethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide
LEVO-0111074-82-4potassium 1,3-dioxoisoindolin-2-ide
LEVO-0121237261-65-2(1S,2R)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide

Frequently asked questions

What are the approved indications of Levomilnacipran Hydrochloride?

Approved indications include: 重度抑郁症.

When does the Levomilnacipran Hydrochloride patent expire?

No public expiry year is available for Levomilnacipran Hydrochloride yet; this page updates once verified.

How many synthesis routes are recorded for Levomilnacipran Hydrochloride?

4 synthesis routes are recorded; the shortest is 2 steps with 10.95 kg (Levomilnacipran Hydrochloride) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Levomilnacipran Hydrochloride intermediates?

1 intermediate CAS of Levomilnacipran Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Levomilnacipran Hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24