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CAS 51594-55-9
(R)-2-(chloromethyl)oxirane(2R)-2-(Chloromethyl)oxirane
Codes：LEVO-004、Atorvastatin-079
Application context (from source-drug indications)
重度抑郁症盐酸左米那普仑缺血性卒中盐酸左米那普仑抑郁盐酸左米那普仑高脂血症阿托伐他汀锶蛛网膜下腔出血阿托伐他汀锶高血压阿托伐他汀锶
Source drugs (routes using this intermediate)
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(R)-2-(chloromethyl)oxirane→2-phenylacetonitrile→(1S,2R)-2-(hydroxymethyl)-1-phenylcyclopropanecarbonitrile→(1S,2R)-2-(hydroxymethyl)-1-phenylcyclopropanecarboxylic acid→(1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one→(1S,2R)-N,N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropanecarboxamide→(1S,2R)-2-(chloromethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide→potassium 1,3-dioxoisoindolin-2-ide→(1S,2R)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide
(3R)-3-Hydroxyhex-5-enenitrile→Chlorido(ethenyl)magnesium→(2R)-1-Chloropent-4-en-2-ol→(3R)-3-[(Trimethylsilyl)oxy]hex-5-enenitrile→tert-Butyl (5R)-5-hydroxy-3-oxooct-7-enoate→tert-Butyl [(4R,6R)-6-[(2E)-2-(hydroxyimino)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate→tert-Butyl (3R,5R)-3,5-dihydroxyoct-7-enoate→tert-Butyl [(4R,6R)-6-allyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate→tert-Butyl [(4R,6S)-2,2-dimethyl-6-(2-oxoethyl)-1,3-dioxan-4-yl]acetate→Hydroxylamine hydrochloric acid→(4R)-2,2-Dimethyl-6beta-(2-hydroxyethyl)-1,3-dioxane-4beta-acetic acid tert-butyl ester→tert-Butyl [(4R,6R)-6-[2-[(methanesulfonyl)oxy]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate→tert-Butyl [(4R,6R)-6-(2-azidoethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate→(2R)-2-(Chloromethyl)oxirane→1-Methoxy-1-methylethyl methyl ether→1,1-Dimethylethyl monobromoacetate→(4R,6R)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester→1,1-Dimethylethyl acetate→Methyl (3R)-3-hydroxyhex-5-enoate
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