维贝格隆
Tier C — Watch / tradeVibegron · all drugs expiring in 2031 →
Targets：ADRB3
Brand：Gemtesa、Beova、OBGEMSA
Indications (approved)：膀胱过度活动症、尿失禁
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| VIBE-001 | 163625-46-5Available | (4S,5R)-tert-butyl 4-formyl-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate |
| VIBE-002 | 2136-75-6Available | 2-(triphenylphosphoranylidene)acetaldehyde |
| VIBE-003 | 1190391-87-7Available | (4R,5R)-tert-butyl 2,2-dimethyl-4-((E)-3-oxoprop-1-en-1-yl)-5-phenyloxazolidine-3-carboxylate |
| VIBE-004 | 1190391-88-8Available | (4R,5R)-tert-butyl 2,2-dimethyl-4-(3-oxopropyl)-5-phenyloxazolidine-3-carboxylate |
| VIBE-005 | 2767-70-6Available | (4-nitrobenzyl)triphenylphosphonium bromide |
| VIBE-006 | 1190391-89-9Available | (4R,5R)-tert-butyl 2,2-dimethyl-4-((E)-4-(4-nitrophenyl)but-3-en-1-yl)-5-phenyloxazolidine-3-carboxylate |
| VIBE-007 | 1190391-90-2Available | (2R,5S)-tert-butyl 2-((R)-hydroxy(phenyl)methyl)-5-(4-nitrobenzyl)pyrrolidine-1-carboxylate |
| VIBE-008 | 1190391-85-5Available | (2S,5R)-tert-butyl 2-(4-aminobenzyl)-5-((R)-hydroxy(phenyl)methyl)pyrrolidine-1-carboxylate |
| VIBE-009 | 1190392-22-3Available | (S)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylic acid |
| VIBE-010 | 1190393-25-9Available | (2R,5S)-tert-butyl 2-((R)-hydroxy(phenyl)methyl)-5-(4-((S)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxamido)benzyl)pyrrolidine-1-carboxylate |
| VIBE-011 | 173142-47-7Available | (S)-methyl 5-methoxy-3,4-dihydro-2H-pyrrole-2-carboxylate |
| VIBE-012 | 14735-70-7Available | 3-azatricyclo[4.2.1.02,5]non-7-en-4-one |
| VIBE-013 | 1190392-23-4Available | (S)-methyl 4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylate |
| Code | CAS No. | Intermediate |
|---|---|---|
| VIBE-012 | 14735-70-7Available | 3-azatricyclo[4.2.1.02,5]non-7-en-4-one |
| VIBE-013 | 1190392-23-4Available | (S)-methyl 4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylate |
| VIBE-014 | 5390-04-5Available | pent-4-yn-1-ol |
| VIBE-015 | 29329-03-1Available | hex-5-ynal |
| VIBE-016 | 1628836-07-6Available | tert-butyl (1-cyanopent-4-yn-1-yl)carbamate |
| VIBE-017 | 1437235-48-7Available | tert-butyl (1-oxo-1-phenylhex-5-yn-2-yl)carbamate |
| VIBE-018 | 1437235-52-3Available | tert-butyl ((1R,2R)-1-hydroxy-1-phenylhex-5-yn-2-yl)carbamate |
| VIBE-019 | 636-98-6Available | 1-iodo-4-nitrobenzene |
| VIBE-020 | 1628836-08-7Available | (1R,2R)-2-amino-6-(4-nitrophenyl)-1-phenylhex-5-yn-1-ol hydrochloride |
| VIBE-021 | 1295539-30-8Available | (R)-((2R,5S)-5-(4-aminobenzyl)pyrrolidin-2-yl)(phenyl)methanol |
| VIBE-022 | 4931-66-2Available | (S)-methyl 5-oxopyrrolidine-2-carboxylate |
Frequently asked questions
What are the approved indications of Vibegron?
Approved indications include: 膀胱过度活动症, 尿失禁.
When does the Vibegron patent expire?
Based on public sources, the Vibegron patent expires in 2031.
How many synthesis routes are recorded for Vibegron?
2 synthesis routes are recorded; the shortest is 9 steps with 1.23 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Vibegron intermediates?
22 intermediate CAS of Vibegron are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Vibegron intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24