CAS 2136-75-6

2-(triphenylphosphoranylidene)acetaldehyde

Codes：RUXO-017、VIBE-002

Application context (from source-drug indications)

特应性皮炎磷酸芦可替尼白癜风磷酸芦可替尼移植物抗宿主病磷酸芦可替尼骨髓纤维化磷酸芦可替尼真性红细胞增多症磷酸芦可替尼膀胱过度活动症维贝格隆尿失禁维贝格隆

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
磷酸芦可替尼Ruxolitinib Phosphate	Tier A — Act now	2028
维贝格隆Vibegron	Tier C — Watch / trade	2031

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

磷酸芦可替尼优化路线steps: 4total yield: /

(4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate→(R)-(4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate→cyclopentanecarbaldehyde→2-(triphenylphosphoranylidene)acetaldehyde→(E)-3-cyclopentylacrylaldehyde→(R)-(4-(1-(1-cyclopentyl-3-oxopropyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate

维贝格隆原研路线steps: 9total yield: 1.23 g

(4S,5R)-tert-butyl 4-formyl-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate→2-(triphenylphosphoranylidene)acetaldehyde→(4R,5R)-tert-butyl 2,2-dimethyl-4-((E)-3-oxoprop-1-en-1-yl)-5-phenyloxazolidine-3-carboxylate→(4R,5R)-tert-butyl 2,2-dimethyl-4-(3-oxopropyl)-5-phenyloxazolidine-3-carboxylate→(4-nitrobenzyl)triphenylphosphonium bromide→(4R,5R)-tert-butyl 2,2-dimethyl-4-((E)-4-(4-nitrophenyl)but-3-en-1-yl)-5-phenyloxazolidine-3-carboxylate→(2R,5S)-tert-butyl 2-((R)-hydroxy(phenyl)methyl)-5-(4-nitrobenzyl)pyrrolidine-1-carboxylate→(2S,5R)-tert-butyl 2-(4-aminobenzyl)-5-((R)-hydroxy(phenyl)methyl)pyrrolidine-1-carboxylate→(S)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylic acid→(2R,5S)-tert-butyl 2-((R)-hydroxy(phenyl)methyl)-5-(4-((S)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxamido)benzyl)pyrrolidine-1-carboxylate→(S)-methyl 5-methoxy-3,4-dihydro-2H-pyrrole-2-carboxylate→3-azatricyclo[4.2.1.02,5]non-7-en-4-one→(S)-methyl 4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylate

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	-CYCLOPENTYLACRYLONITRILE Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	Cyclopentanecarbaldehyde Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	4-Chloropyrrolo[2,3-d]pyrimidine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	4-(1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	(3R)-3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	(S)-3-cyclopentyl-3-hydrazinylpropanenitrile L-tartaric acid salt dihydrate Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	2-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetic acid Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	4-methyl-7H-pyrrolo[2,3-d]pyrimidine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	(R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	(4-(1-(2-Cyano-1-cyclopentylethyl)-1h-pyrazol-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	4-CHLORO-7-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-7H-PYRROLO[2,3-D]PYRIMIDINE Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	1H-Pyrazole-1-propanamide, 4-bromo-β-cyclopentyl-, (βR)- Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	(R)-3-(4-broMo-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	(R)-3-cyclopentyl-3-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanenitrile Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	3-Cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	(6S)-4,6,7,8-tetrahydro-4-oxo-Pyrrolo[1,2-a]pyriMidine-6-carboxylic acid Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	tert-butyl(4-(3-(dimethoxyphosphoryl)-2-oxopropyl)phenyl)carbamate Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	(1R,2R)-2-amino-6-(4-nitrophenyl)-1-phenylhex-5-yn-1-olhydrochloride Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	(R)-((2R,5S)-5-(4-aminobenzyl)pyrrolidin-2-yl)(phenyl)methanol Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	tert-butyl(4R,5R)-4-(hydroxymethyl)-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	tert-butyl(4R,5R)-4-((E)-4-(4-((tert-butoxycarbonyl)amino)phenyl)-3-oxobut-1-en-1-yl)-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate Pharmaceutical Intermediates	询价	询价	询价	—

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