Deuterated ruxolitinib
Tier C — Watch / tradeDeuterated ruxolitinib
Targets：JAK2, JAK1
Brand：LEQSELVI
Indications (approved)：Alopecia areata
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| D-RUXO-001 | 68375-92-8 | 1,4-dibromobutane-1,1,2,2,3,3,4,4-d8 |
| D-RUXO-002 | 105-53-3Available | diethyl malonate |
| D-RUXO-003 | 1254047-32-9 | diethyl cyclopentane-1,1-dicarboxylate-d8 |
| D-RUXO-004 | 1513884-11-1 | cyclopentane-1-carboxylic-2,2,3,3,4,4,5,5-d8 acid |
| D-RUXO-005 | 1801457-17-9 | N-methoxy-N-methylcyclopentane-1-carboxamide-2,2,3,3,4,4,5,5-d8 |
| D-RUXO-006 | - | cyclopentane-2,2,3,3,4,4,5,5-d8-1-carbaldehyde |
| D-RUXO-007 | - | (E)-3-(cyclopentyl-2,2,3,3,4,4,5,5-d8)acrylonitrile |
| D-RUXO-008 | 1146629-77-7Available | (4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate |
| D-RUXO-009 | - | (4-(1-(2-cyano-1-(cyclopentyl-2,2,3,3,4,4,5,5-d8)ethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate |
| D-RUXO-010 | - | (R)-(4-(1-(2-cyano-1-(cyclopentyl-2,2,3,3,4,4,5,5-d8)ethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate |
| Deuterated Ruxolitinib | 1513883-39-0 | (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-(cyclopentyl-2,2,3,3,4,4,5,5-d8)propanenitrile |
Frequently asked questions
What are the approved indications of Deuterated ruxolitinib?
Approved indications include: Alopecia areata.
When does the Deuterated ruxolitinib patent expire?
No public expiry year is available for Deuterated ruxolitinib yet; this page updates once verified.
How many synthesis routes are recorded for Deuterated ruxolitinib?
1 synthesis routes are recorded; the shortest is 8 steps with 19 mg (Deuterated Ruxolitinib) total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Deuterated ruxolitinib intermediates?
2 intermediate CAS of Deuterated ruxolitinib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Deuterated ruxolitinib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-27