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CAS 1801457-17-9
N-methoxy-N-methylcyclopentane-1-carboxamide-2,2,3,3,4,4,5,5-d8
Codes: D-RUXO-005
Application context (from source-drug indications)
Alopecia areataDeuterated ruxolitinibRenal impairmentDeuterated ruxolitinibHepatic function declineDeuterated ruxolitinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Deuterated ruxolitinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,4-dibromobutane-1,1,2,2,3,3,4,4-d8→diethyl malonate→diethyl cyclopentane-1,1-dicarboxylate-d8→cyclopentane-1-carboxylic-2,2,3,3,4,4,5,5-d8 acid→N-methoxy-N-methylcyclopentane-1-carboxamide-2,2,3,3,4,4,5,5-d8→cyclopentane-2,2,3,3,4,4,5,5-d8-1-carbaldehyde→(E)-3-(cyclopentyl-2,2,3,3,4,4,5,5-d8)acrylonitrile→(4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate→(4-(1-(2-cyano-1-(cyclopentyl-2,2,3,3,4,4,5,5-d8)ethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate→(R)-(4-(1-(2-cyano-1-(cyclopentyl-2,2,3,3,4,4,5,5-d8)ethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate→(R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-(cyclopentyl-2,2,3,3,4,4,5,5-d8)propanenitrile
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