Netarsudil Dimesylate
Tier C — Watch / tradeNetarsudil Dimesylate
Targets：ROCKs、NET
Brand：Rhopressa
Indications (approved)：高眼压、开角型青光眼
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| NETA-001 | 73401-74-8 | 2-(4-(hydroxymethyl)phenyl)acetic acid |
| NETA-002 | 18107-18-1 | (diazomethyl)trimethylsilane |
| NETA-003 | 155380-11-3 | methyl 2-[4-(hydroxymethyl)phenyl]acetate |
| NETA-004 | 1253955-08-6 | methyl 2-(4-(hydroxymethyl)phenyl)acetate |
| NETA-005 | 5332-26-3 | methyl 2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)acetate |
| NETA-006 | 1253955-09-7 | 2-(bromomethyl)isoindoline-1,3-dione |
| NETA-007 | 1253955-10-0 | methyl 3-(1,3-dioxoisoindolin-2-yl)-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propanoate |
| NETA-008 | 23687-26-5 | 2-((2-carboxy-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)ethyl)carbamoyl)benzoic acid |
| NETA-009 | 1253955-11-1 | isoquinolin-6-amine |
| NETA-010 | 1253955-12-2 | 3-(1,3-dioxoisoindolin-2-yl)-N-(isoquinolin-6-yl)-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propanamide |
| NETA-011 | 1253955-13-3 | 3-amino-N-(isoquinolin-6-yl)-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propanamide |
| NETA-012 | 1253955-14-4 | tert-butyl (3-(isoquinolin-6-ylamino)-3-oxo-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propyl)carbamate |
| NETA-013 | 611-01-8 | 2,4-dimethylbenzoic acid |
| NETA-014 | 1253955-17-7 | 4-(3-((tert-butoxycarbonyl)amino)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate |
| NETA-015 | 1253955-19-9 | (S)-4-(3-((tert-butoxycarbonyl)amino)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate |
| Code | CAS No. | Intermediate |
|---|---|---|
| NETA-003 | 155380-11-3 | methyl 2-[4-(hydroxymethyl)phenyl]acetate |
| NETA-008 | 23687-26-5 | 2-((2-carboxy-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)ethyl)carbamoyl)benzoic acid |
| NETA-015 | 1253955-19-9 | (S)-4-(3-((tert-butoxycarbonyl)amino)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate |
| NETA-016 | 1253955-08-6 | methyl 2-(4-(hydroxymethyl)phenyl)acetate |
| NETA-017 | 611-01-8 | 2,4-dimethylbenzoic acid |
| NETA-018 | 2097334-15-9 | 4-(2-methoxy-2-oxoethyl)benzyl 2,4-dimethylbenzoate |
| NETA-019 | 183072-03-9 | (R)-5-benzyloxazolidin-2-one |
| NETA-020 | - | (R)-4-(2-(5-benzyl-2-oxooxazolidin-3-yl)-2-oxoethyl)benzyl 2,4-dimethylbenzoate |
| NETA-021 | 305860-41-7 | tert-butyl ((1H-benzo[d][1,2,3]triazol-1-yl)methyl)carbamate |
| NETA-022 | - | 4-((S)-1-((R)-5-benzyl-2-oxooxazolidin-3-yl)-3-((tert-butoxycarbonyl)amino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate |
| NETA-023 | 2097334-20-6 | (S)-3-((tert-butoxycarbonyl)amino)-2-(4-(((2,4-dimethylbenzoyl)oxy)methyl)phenyl)propanoic acid |
| NETA-024 | 66270-36-8 | 1,1,1-trichloro-2-methylpropan-2-yl carbonochloridate |
Frequently asked questions
What are the approved indications of Netarsudil Dimesylate?
Approved indications include: 高眼压, 开角型青光眼.
When does the Netarsudil Dimesylate patent expire?
No public expiry year is available for Netarsudil Dimesylate yet; this page updates once verified.
How many synthesis routes are recorded for Netarsudil Dimesylate?
2 synthesis routes are recorded; the shortest is 7 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Netarsudil Dimesylate intermediates?
All intermediates in Netarsudil Dimesylate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Netarsudil Dimesylate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24