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CAS 1253955-10-0
methyl 3-(1,3-dioxoisoindolin-2-yl)-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propanoate
Codes：NETA-007
Application context (from source-drug indications)
高眼压Netarsudil Dimesylate开角型青光眼Netarsudil DimesylateFuchs角膜内皮营养不良Netarsudil Dimesylate角膜水肿Netarsudil Dimesylate青光眼Netarsudil Dimesylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Netarsudil DimesylateNetarsudil Dimesylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(4-(hydroxymethyl)phenyl)acetic acid→(diazomethyl)trimethylsilane→methyl 2-[4-(hydroxymethyl)phenyl]acetate→methyl 2-(4-(hydroxymethyl)phenyl)acetate→methyl 2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)acetate→2-(bromomethyl)isoindoline-1,3-dione→methyl 3-(1,3-dioxoisoindolin-2-yl)-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propanoate→2-((2-carboxy-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)ethyl)carbamoyl)benzoic acid→isoquinolin-6-amine→3-(1,3-dioxoisoindolin-2-yl)-N-(isoquinolin-6-yl)-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propanamide→3-amino-N-(isoquinolin-6-yl)-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propanamide→tert-butyl (3-(isoquinolin-6-ylamino)-3-oxo-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propyl)carbamate→2,4-dimethylbenzoic acid→4-(3-((tert-butoxycarbonyl)amino)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate→(S)-4-(3-((tert-butoxycarbonyl)amino)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate
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