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达罗他胺

Tier B — Position early

Darolutamide · all drugs expiring in 2031 →

芬兰奥立安集团
Originator
2019
First approval
2031
Expiry (public)
$2.7B ▲
Peak sales
化学药
Type

Targets：AR

Brand：Nubeqa、诺倍戈

Indications (approved)：激素敏感性前列腺肿瘤、去势敏感性前列腺肿瘤、前列腺癌、去势抵抗性前列腺肿瘤

Regional status

US
批准上市
2019-07-30
EU
批准上市
2020-03-27
China
批准上市
2021-02-02
Japan
批准上市
2020-01-23

Synthetic routes & intermediates1 routes

Originator routes × 1Optimised (non-patent) × 0Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 6 · Total yield 12.2g
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
ODM-201-001154607-01-9Available4-bromo-2-chlorobenzonitrile
ODM-201-002903550-26-5Available1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
ODM-201-0031297537-35-9Available2-chloro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzonitrile
ODM-201-0041297537-39-3Available2-chloro-4-(1H-pyrazol-3-yl)benzonitrile hydrochloride
ODM-201-0051297537-37-1Available2-chloro-4-(1H-pyrazol-3-yl)benzonitrile
ODM-201-00679069-13-9Availabletert-butyl (S)-(1-hydroxypropan-2-yl)carbamate
ODM-201-0071297537-41-7Available(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile
ODM-201-0081297537-45-1Available5-acetyl-1H-pyrazole-3-carboxylic acid
ODM-201-0091297537-33-7Available(S)-5-acetyl-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

Frequently asked questions

What are the approved indications of Darolutamide?

Approved indications include: 激素敏感性前列腺肿瘤, 去势敏感性前列腺肿瘤, 前列腺癌, 去势抵抗性前列腺肿瘤.

When does the Darolutamide patent expire?

Based on public sources, the Darolutamide patent expires in 2031.

How many synthesis routes are recorded for Darolutamide?

1 synthesis routes are recorded; the shortest is 6 steps with 12.2g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Darolutamide intermediates?

9 intermediate CAS of Darolutamide are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Darolutamide intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24