← Back to patent-cliff list
Atogepant
Tier C — Watch / tradeAtogepant
Merck & Co Inc
Originator
2021
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：CGRPR
Brand：Aquipta, QULIPTA, Qulipta
Indications (approved)：Migraine
Regional status
US
Approved
2021-09-28
EU
Approved
2023-08-11
China
Filed / under review
2026-01-08
Japan
Approved
2026-02-19
Synthetic routes & intermediates7 routes
Originator routes × 2Optimised (non-patent) × 5Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 8 · Total yield 5.4 g
MK-8031-001114152-23-7MK-8031-002—MK-8031-0031305324-34-8MK-8031-0041456803-29-4MK-8031-005—MK-8031-0061456803-42-1MK-8031-007—MK-8031-0086226-25-1MK-8031-0091375471-12-7MK-8031-0101375794-72-1MK-8031-0111375541-21-1API · Atogepant
| Code | CAS No. | Intermediate |
|---|---|---|
| MK-8031-001 | 114152-23-7Available | 2-(2,3,6-trifluorophenyl)acetic acid |
| MK-8031-002 | - | N-methoxy-N-methyl-2-(2,3,6-trifluorophenyl)acetamide |
| MK-8031-003 | 1305324-34-8Available | 1-(2,3,6-trifluorophenyl)propan-2-one |
| MK-8031-004 | 1456803-29-4Available | isopropyl N-(tert-butoxycarbonyl)-O-(methylsulfonyl)serinate |
| MK-8031-005 | - | tert-butyl 2-((tert-butoxycarbonyl)amino)-5-oxo-4-(2,3,6-trifluorophenyl)hexanoate |
| MK-8031-006 | 1456803-42-1Available | tert-butyl ((5S,6R)-6-methyl-2-oxo-5-(2,3,6-trifluorophenyl)piperidin-3-yl)carbamate |
| MK-8031-007 | - | tert-butyl ((3S,5S,6R)-6-methyl-2-oxo-5-(2,3,6-trifluorophenyl)piperidin-3-yl)carbamate |
| MK-8031-008 | 6226-25-1Available | 2,2,2-trifluoroethyl trifluoromethanesulfonate |
| MK-8031-009 | 1375471-12-7Available | tert-butyl ((5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)carbamate |
| MK-8031-010 | 1375794-72-1Available | (3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-aminium acetyl-L-phenylalaninate |
| MK-8031-011 | 1375541-21-1Available | (S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic acid |
OriginatorRoute 7Steps 3 · Total yield 5.40 g
MK-8031-055367-23-7MK-8031-0561456803-49-8MK-8031-0571456803-50-1API · Atogepant
| Code | CAS No. | Intermediate |
|---|---|---|
| MK-8031-055 | 367-23-7Available | 1,2,4-trifluorobenzene |
| MK-8031-056 | 1456803-49-8Available | 3-hydroxy-3-(2,3,6-trifluorophenyl)butan-2-one |
| MK-8031-057 | 1456803-50-1Available | 3-(2,3,6-trifluorophenyl)but-3-en-2-one |
OptimisedRoute 2Steps 8 · Total yield /
MK-8031-01254923-31-8MK-8031-0136226-25-1MK-8031-0141375471-02-5MK-8031-015247564-71-2MK-8031-016—MK-8031-017—MK-8031-0181375471-11-6MK-8031-0191375471-12-7API · Atogepant
| Code | CAS No. | Intermediate |
|---|---|---|
| MK-8031-012 | 54923-31-8Available | 5-bromo-6-methylpyridin-2(1H)-one |
| MK-8031-013 | 6226-25-1Available | 2,2,2-trifluoroethyl trifluoromethanesulfonate |
| MK-8031-014 | 1375471-02-5Available | 5-bromo-6-methyl-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one |
| MK-8031-015 | 247564-71-2Available | (2,3,6-trifluorophenyl)boronic acid |
| MK-8031-016 | - | 6-methyl-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)pyridin-2(1H)-one |
| MK-8031-017 | - | (5S,6R)-6-methyl-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-2-one |
| MK-8031-018 | 1375471-11-6Available | (5S,6R)-3-azido-6-methyl-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-2-one |
| MK-8031-019 | 1375471-12-7Available | tert-butyl ((5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)carbamate |
OptimisedRoute 3Steps 11 · Total yield /
MK-8031-020271-63-6MK-8031-021879132-46-4MK-8031-022879132-47-5MK-8031-023879132-48-6MK-8031-02452011-50-4MK-8031-025957122-45-1MK-8031-02614150-94-8MK-8031-027957122-46-2MK-8031-028957122-47-3MK-8031-029957122-44-0MK-8031-0301059186-43-4MK-8031-0311189570-15-7MK-8031-0321375541-24-4API · Atogepant
| Code | CAS No. | Intermediate |
|---|---|---|
| MK-8031-020 | 271-63-6Available | 1H-pyrrolo[2,3-b]pyridine |
| MK-8031-021 | 879132-46-4Available | 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine |
| MK-8031-022 | 879132-47-5Available | 3,3-dibromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one |
| MK-8031-023 | 879132-48-6Available | 1-((2-(trimethylsilyl)ethoxy)methyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one |
| MK-8031-024 | 52011-50-4Available | 1,4-dibromobutan-2-one |
| MK-8031-025 | 957122-45-1Available | 1'-((2-(trimethylsilyl)ethoxy)methyl)spiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridine]-2',3(1'H)-dione |
| MK-8031-026 | 14150-94-8Available | 1-methyl-3,5-dinitropyridin-2(1H)-one |
| MK-8031-027 | 957122-46-2Available | 3-nitro-1'-((2-(trimethylsilyl)ethoxy)methyl)-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one |
| MK-8031-028 | 957122-47-3Available | 3-amino-1'-((2-(trimethylsilyl)ethoxy)methyl)-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one |
| MK-8031-029 | 957122-44-0Available | 3-amino-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one |
| MK-8031-030 | 1059186-43-4Available | (R)-3-amino-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one |
| MK-8031-031 | 1189570-15-7Available | (R)-3-iodo-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one |
| MK-8031-032 | 1375541-24-4Available | methyl (R)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylate |
OptimisedRoute 4Steps 5 · Total yield /
MK-8031-03389-00-9MK-8031-03498555-51-2MK-8031-0351356330-71-6MK-8031-0361318253-26-7MK-8031-0371375542-65-6API · Atogepant
| Code | CAS No. | Intermediate |
|---|---|---|
| MK-8031-033 | 89-00-9Available | pyridine-2,3-dicarboxylic acid |
| MK-8031-034 | 98555-51-2Available | dimethyl 5-bromopyridine-2,3-dicarboxylate |
| MK-8031-035 | 1356330-71-6Available | (5-bromopyridine-2,3-diyl)dimethanol hydrochloride |
| MK-8031-036 | 1318253-26-7Available | 3-bromo-1'-((2-(trimethylsilyl)ethoxy)methyl)-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one |
| MK-8031-037 | 1375542-65-6Available | methyl (S)-2'-oxo-1'-((2-(trimethylsilyl)ethoxy)methyl)-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylate |
OptimisedRoute 5Steps 9 · Total yield 3.1 g
MK-8031-038137628-17-2MK-8031-0391227585-65-0MK-8031-0401455358-05-1MK-8031-0411455358-06-1MK-8031-042—MK-8031-0431455358-11-8MK-8031-0441455358-12-9MK-8031-045—MK-8031-0461455358-14-1MK-8031-0471455358-16-3MK-8031-048—MK-8031-04919614-12-1API · Atogepant
| Code | CAS No. | Intermediate |
|---|---|---|
| MK-8031-038 | 137628-17-2Available | 2,3-dibromo-5-chloropyridine |
| MK-8031-039 | 1227585-65-0Available | (2-bromo-5-chloropyridin-3-yl)methanol |
| MK-8031-040 | 1455358-05-1Available | 5-chloro-3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)picolinaldehyde |
| MK-8031-041 | 1455358-06-1Available | 1-(tert-butyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one |
| MK-8031-042 | - | (E)-1-(tert-butyl)-3-((5-chloro-3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)pyridin-2-yl)methylene)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one |
| MK-8031-043 | 1455358-11-8Available | 1-(tert-butyl)-3-((5-chloro-3-(hydroxymethyl)pyridin-2-yl)methyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one |
| MK-8031-044 | 1455358-12-9Available | 1-(tert-butyl)-3-((5-chloro-3-(chloromethyl)pyridin-2-yl)methyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one |
| MK-8031-045 | - | (1S,2R,4S,5R)-1-(2-bromo-5-methoxybenzyl)-2-((S)-(1-(2-bromo-5-methoxybenzyl)-6-methylquinolin-1-ium-4-yl)(hydroxy)methyl)-5-vinylquinuclidin-1-ium |
| MK-8031-046 | 1455358-14-1Available | (S)-1'-(tert-butyl)-3-chloro-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one |
| MK-8031-047 | 1455358-16-3Available | (S)-1'-(tert-butyl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic acid |
| MK-8031-048 | - | (S)-(6-methylquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol |
| MK-8031-049 | 19614-12-1Available | 1-bromo-2-(bromomethyl)-4-methoxybenzene |
OptimisedRoute 6Steps 5 · Total yield 3.75 g
MK-8031-050—MK-8031-051—MK-8031-052—MK-8031-0531455358-36-7MK-8031-054—API · Atogepant
| Code | CAS No. | Intermediate |
|---|---|---|
| MK-8031-050 | - | 2-bromo-5-chloro-3-(((triisopropylsilyl)oxy)methyl)pyridine |
| MK-8031-051 | - | methyl 5-chloro-3-(((triisopropylsilyl)oxy)methyl)picolinate |
| MK-8031-052 | - | 5-chloro-2-(chloromethyl)-3-(((triisopropylsilyl)oxy)methyl)pyridine |
| MK-8031-053 | 1455358-36-7Available | methyl 1-(tert-butyl)-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-3-carboxylate |
| MK-8031-054 | - | methyl 1-(tert-butyl)-3-((5-chloro-3-((triisopropylsilyl)oxy)pyridin-2-yl)methyl)-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-3-carboxylate |
Frequently asked questions
What are the approved indications of Atogepant?
Approved indications include: Migraine.
When does the Atogepant patent expire?
No public expiry year is available for Atogepant yet; this page updates once verified.
How many synthesis routes are recorded for Atogepant?
7 synthesis routes are recorded; the shortest is 3 steps with 5.40 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Atogepant intermediates?
43 intermediate CAS of Atogepant are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Atogepant intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-27