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CAS 1305324-34-8
1-(2,3,6-trifluorophenyl)propan-2-one
Codes: MK-8031-003
Application context (from source-drug indications)
MigraineAtogepant
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Atogepant | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(2,3,6-trifluorophenyl)acetic acid→N-methoxy-N-methyl-2-(2,3,6-trifluorophenyl)acetamide→1-(2,3,6-trifluorophenyl)propan-2-one→isopropyl N-(tert-butoxycarbonyl)-O-(methylsulfonyl)serinate→tert-butyl 2-((tert-butoxycarbonyl)amino)-5-oxo-4-(2,3,6-trifluorophenyl)hexanoate→tert-butyl ((5S,6R)-6-methyl-2-oxo-5-(2,3,6-trifluorophenyl)piperidin-3-yl)carbamate→tert-butyl ((3S,5S,6R)-6-methyl-2-oxo-5-(2,3,6-trifluorophenyl)piperidin-3-yl)carbamate→2,2,2-trifluoroethyl trifluoromethanesulfonate→tert-butyl ((5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)carbamate→(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-aminium acetyl-L-phenylalaninate→(S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic acid
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | L-Phenylalanine, N-acetyl-, compd. with (3S,5S,6R)-3-amino-6-methyl-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)-2-piperidinone (1:1) Pharmaceutical Intermediates | On request | On request | On request | — |
| Unibest Taizhou GMP-like Site | 1456803-42-1 Pharmaceutical Intermediates | On request | On request | On request | — |
| Qualified Partner — East China API Works | tert-butyl ((3S,5S,6R)-6-methyl-2-oxo-5-(2,3,6-trifluorophenyl)piperidin-3-yl)carbamate Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.