阿帕他胺
Tier A — Act nowApalutamide · all drugs expiring in 2030 →
Targets：AR
Brand：安森珂、Erleada
Indications (approved)：去势抵抗性前列腺肿瘤、前列腺癌
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| APAL-001 | 22245-83-6Available | 3-(trifluoromethyl)pyridin-2-ol |
| APAL-002 | 887707-23-5Available | 5-iodo-3-(trifluoromethyl)pyridin-2-ol |
| APAL-003 | 887707-25-7Available | 2-chloro-5-iodo-3-(trifluoromethyl)pyridine |
| APAL-004 | 2393-23-9Available | (4-methoxyphenyl)methanamine |
| APAL-005 | 956104-44-2Available | 6-chloro-N-(4-methoxybenzyl)-5-(trifluoromethyl)pyridin-3-amine |
| APAL-006 | 956104-45-3Available | 5-((4-methoxybenzyl)amino)-3-(trifluoromethyl)picolinonitrile |
| APAL-007 | 573762-62-6Available | 5-amino-3-(trifluoromethyl)picolinonitrile |
| APAL-008 | 951753-87-0Available | 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile |
| APAL-009 | 915087-26-2Available | 4-((1-cyanocyclobutyl)amino)-2-fluoro-N-methylbenzamide |
| APAL-010 | 72482-64-5Available | 2,4-difluorobenzoyl chloride |
| APAL-011 | 948717-18-8Available | 2,4-difluoro-N-methylbenzamide |
| APAL-012 | 956104-46-4Available | 2-fluoro-4-((4-methoxybenzyl)amino)-N-methylbenzamide |
| APAL-013 | 915087-25-1Available | 4-amino-2-fluoro-N-methylbenzamide |
| APAL-014 | 1191-95-3Available | cyclobutanone |
| Code | CAS No. | Intermediate |
|---|---|---|
| APAL-001 | 22245-83-6Available | 3-(trifluoromethyl)pyridin-2-ol |
| APAL-007 | 573762-62-6Available | 5-amino-3-(trifluoromethyl)picolinonitrile |
| APAL-008 | 951753-87-0Available | 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile |
| APAL-009 | 915087-26-2Available | 4-((1-cyanocyclobutyl)amino)-2-fluoro-N-methylbenzamide |
| APAL-015 | 65753-47-1Available | 2-chloro-3-(trifluoromethyl)pyridine |
| APAL-016 | 99368-66-8Available | 5-nitro-3-(trifluoromethyl)pyridin-2(1H)-one |
| APAL-017 | 99368-67-9Available | 2-chloro-5-nitro-3-(trifluoromethyl)pyridine |
| APAL-018 | 99368-68-0Available | 6-chloro-5-(trifluoromethyl)pyridin-3-amine |
| APAL-019 | 1057383-91-1Available | tert-butyl (6-chloro-5-(trifluoromethyl)pyridin-3-yl)carbamate |
| APAL-020 | 1165744-14-8Available | tert-butyl (6-cyano-5-(trifluoromethyl)pyridin-3-yl)carbamate |
Frequently asked questions
What are the approved indications of Apalutamide?
Approved indications include: 去势抵抗性前列腺肿瘤, 前列腺癌.
When does the Apalutamide patent expire?
Based on public sources, the Apalutamide patent expires in 2030.
How many synthesis routes are recorded for Apalutamide?
2 synthesis routes are recorded; the shortest is 9 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Apalutamide intermediates?
20 intermediate CAS of Apalutamide are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Apalutamide intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24