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CAS 915087-26-2
4-((1-cyanocyclobutyl)amino)-2-fluoro-N-methylbenzamide
Codes：APAL-009
Application context (from source-drug indications)
去势抵抗性前列腺肿瘤阿帕他胺前列腺癌阿帕他胺
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 阿帕他胺Apalutamide | Tier A — Act now | 2030 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-(trifluoromethyl)pyridin-2-ol→5-iodo-3-(trifluoromethyl)pyridin-2-ol→2-chloro-5-iodo-3-(trifluoromethyl)pyridine→(4-methoxyphenyl)methanamine→6-chloro-N-(4-methoxybenzyl)-5-(trifluoromethyl)pyridin-3-amine→5-((4-methoxybenzyl)amino)-3-(trifluoromethyl)picolinonitrile→5-amino-3-(trifluoromethyl)picolinonitrile→5-isothiocyanato-3-(trifluoromethyl)picolinonitrile→4-((1-cyanocyclobutyl)amino)-2-fluoro-N-methylbenzamide→2,4-difluorobenzoyl chloride→2,4-difluoro-N-methylbenzamide→2-fluoro-4-((4-methoxybenzyl)amino)-N-methylbenzamide→4-amino-2-fluoro-N-methylbenzamide→cyclobutanone
3-(trifluoromethyl)pyridin-2-ol→5-amino-3-(trifluoromethyl)picolinonitrile→5-isothiocyanato-3-(trifluoromethyl)picolinonitrile→4-((1-cyanocyclobutyl)amino)-2-fluoro-N-methylbenzamide→2-chloro-3-(trifluoromethyl)pyridine→5-nitro-3-(trifluoromethyl)pyridin-2(1H)-one→2-chloro-5-nitro-3-(trifluoromethyl)pyridine→6-chloro-5-(trifluoromethyl)pyridin-3-amine→tert-butyl (6-chloro-5-(trifluoromethyl)pyridin-3-yl)carbamate→tert-butyl (6-cyano-5-(trifluoromethyl)pyridin-3-yl)carbamate
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 5-Amino-3-(trifluoromethyl)picolinonitrile Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | N-Boc-1-aminocyclobutanecarboxylic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 1-amino-N-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]Cyclobutanecarboxamide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.