Imiquimod

Tier C — Watch / trade

Imiquimod

3m Healthcare Ltd

Originator

1997

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：TLR7, TLR8

Brand：Beselna, Vyloma, Vesimune, Zyclara, Zartra, Aldara

Indications (approved)：Actinic keratosis, 尖锐湿疣, 角化病, Basal cell carcinoma

Regional status

Approved

1997-02-27

Approved

1998-09-18

China

Approved

2003-02-13

Japan

Approved

2007-07-31

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 7 · Total yield 2.20 g

IMIQ-001611-36-9IMIQ-00250332-66-6IMIQ-00339061-97-7IMIQ-00478-81-9IMIQ-00599009-85-5IMIQ-00699010-09-0IMIQ-00799010-24-9IMIQ-00899010-63-6IMIQ-0094461-33-0IMIQ-010144660-62-8API · Imiquimod

Code	CAS No.	Intermediate
IMIQ-001	611-36-9	quinolin-4-ol
IMIQ-002	50332-66-6	3-nitroquinolin-4-ol
IMIQ-003	39061-97-7	4-chloro-3-nitroquinoline
IMIQ-004	78-81-9	2-methylpropan-1-amine
IMIQ-005	99009-85-5	N-isobutyl-3-nitroquinolin-4-amine
IMIQ-006	99010-09-0	N4-isobutylquinoline-3,4-diamine
IMIQ-007	99010-24-9	1-isobutyl-1H-imidazo[4,5-c]quinoline
IMIQ-008	99010-63-6	1-isobutyl-1H-imidazo[4,5-c]quinoline 5-oxide
IMIQ-009	4461-33-0	benzoyl isocyanate
IMIQ-010	144660-62-8	N-(1-isobutyl-1H-imidazo[4,5-c]quinolin-4-yl)benzamide

OptimisedRoute 2Steps 5 · Total yield 2.30 g

IMIQ-00478-81-9IMIQ-012132521-66-5IMIQ-013133860-75-0IMIQ-014133860-76-1IMIQ-01599010-64-7IMIQ-01115151-57-2API · Imiquimod

Code	CAS No.	Intermediate
IMIQ-004	78-81-9	2-methylpropan-1-amine
IMIQ-012	132521-66-5	2,4-dichloro-3-nitroquinoline
IMIQ-013	133860-75-0	2-chloro-N4-isobutylquinoline-3,4-diamine
IMIQ-014	133860-76-1	4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline
IMIQ-015	99010-64-7	4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline
IMIQ-011	15151-57-2	-

OptimisedRoute 3Steps 5 · Total yield 40.0 g

IMIQ-00699010-09-0IMIQ-00799010-24-9IMIQ-01599010-64-7IMIQ-016896106-14-2IMIQ-017896106-15-3API · Imiquimod

Code	CAS No.	Intermediate
IMIQ-006	99010-09-0	N4-isobutylquinoline-3,4-diamine
IMIQ-007	99010-24-9	1-isobutyl-1H-imidazo[4,5-c]quinoline
IMIQ-015	99010-64-7	4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline
IMIQ-016	896106-14-2	1-isobutyl-1H-imidazo[4,5-c]quinoline 5-oxide hydrochloride
IMIQ-017	896106-15-3	4-iodo-1-isobutyl-1H-imidazo[4,5-c]quinoline

OptimisedRoute 4Steps 4 · Total yield /

IMIQ-00478-81-9IMIQ-0185098-14-6IMIQ-019960253-98-9IMIQ-020960254-00-6IMIQ-021191171-55-8IMIQ-022960254-02-8API · Imiquimod

Code	CAS No.	Intermediate
IMIQ-004	78-81-9	2-methylpropan-1-amine
IMIQ-018	5098-14-6	2-aminomalononitrile 4-methylbenzenesulfonate
IMIQ-019	960253-98-9	5-amino-1-isobutyl-1H-imidazole-4-carbonitrile
IMIQ-020	960254-00-6	5-iodo-1-isobutyl-1H-imidazole-4-carbonitrile
IMIQ-021	191171-55-8	2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
IMIQ-022	960254-02-8	5-(2-aminophenyl)-1-isobutyl-1H-imidazole-4-carbonitrile

OptimisedRoute 5Steps 9 · Total yield /

IMIQ-00478-81-9IMIQ-01599010-64-7IMIQ-0236630-33-7IMIQ-0242999-46-4IMIQ-025851452-91-0IMIQ-026851452-93-2IMIQ-027—IMIQ-028851452-87-4IMIQ-029851452-97-6IMIQ-030851452-81-8IMIQ-03199010-99-8API · Imiquimod

Code	CAS No.	Intermediate
IMIQ-004	78-81-9	2-methylpropan-1-amine
IMIQ-015	99010-64-7	4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline
IMIQ-023	6630-33-7	ethyl 4-(piperazin-1-yl)benzoate
IMIQ-024	2999-46-4	ethyl 2-isocyanoacetate
IMIQ-025	851452-91-0	(Z)-ethyl 3-(2-bromophenyl)-2-formamidoacrylate
IMIQ-026	851452-93-2	(E)-ethyl 3-bromo-3-(2-bromophenyl)-2-formamidoacrylate
IMIQ-027	-	(E)-ethyl 3-bromo-3-(2-bromophenyl)-2-isocyanoacrylate
IMIQ-028	851452-87-4	ethyl 5-(2-bromophenyl)-1-isobutyl-1H-imidazole-4-carboxylate
IMIQ-029	851452-97-6	5-(2-bromophenyl)-1-isobutyl-1H-imidazole-4-carboxylic acid
IMIQ-030	851452-81-8	5-(2-bromophenyl)-1-isobutyl-1H-imidazole-4-carboxamide
IMIQ-031	99010-99-8	1-isobutyl-1H-imidazo[4,5-c]quinolin-4(5H)-one

Frequently asked questions

What are the approved indications of Imiquimod?

Approved indications include: Actinic keratosis, 尖锐湿疣, 角化病, Basal cell carcinoma.

When does the Imiquimod patent expire?

No public expiry year is available for Imiquimod yet; this page updates once verified.

How many synthesis routes are recorded for Imiquimod?

5 synthesis routes are recorded; the shortest is 4 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Imiquimod intermediates?

All intermediates in Imiquimod routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Imiquimod intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-27