可美替尼
Tier C — Watch / tradeCobimetinib Fumarate · all drugs expiring in 2029 →
Targets：MEK2、MEK1
Brand：Cotellic
Indications (approved)：黑色素瘤
Regional status
Synthetic routes & intermediates3 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| COBI-001 | 18621-18-6 | azetidin-3-ol hydrochloride |
| COBI-002 | 128117-22-6 | benzyl 3-hydroxyazetidine-1-carboxylate |
| COBI-003 | 105258-93-3 | benzyl 3-oxoazetidine-1-carboxylate |
| COBI-004 | 75844-69-8 | tert-butyl piperidine-1-carboxylate |
| COBI-005 | 934664-27-4 | tert-butyl 2-(1-((benzyloxy)carbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate |
| COBI-006 | 39637-99-5 | (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl chloride |
| COBI-007 | 934665-53-9 | (S)-tert-butyl 2-(1-((benzyloxy)carbonyl)-3-(((R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl)oxy)azetidin-3-yl)piperidine-1-carboxylate |
| COBI-008 | 934665-55-1 | (S)-tert-butyl 2-(1-((benzyloxy)carbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate |
| COBI-009 | 934666-39-4 | (S)-tert-butyl 2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate |
| COBI-010 | 934664-19-4 | 3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl fluoride |
| COBI-011 | 934663-52-2 | (S)-tert-butyl 2-(1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate |
| COBI-012 | 61079-72-9 | 2,3,4-trifluorobenzoic acid |
| COBI-013 | 29632-74-4Available | 2-fluoro-4-iodoaniline |
| COBI-014 | 391211-97-5 | 3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid |
| COBI-015 | 675-14-9 | 2,4,6-trifluoro-1,3,5-triazine |
| Code | CAS No. | Intermediate |
|---|---|---|
| COBI-012 | 61079-72-9 | 2,3,4-trifluorobenzoic acid |
| COBI-013 | 29632-74-4Available | 2-fluoro-4-iodoaniline |
| COBI-016 | 106565-71-3 | (3S,5R,8aS)-3-phenylhexahydro-2H-oxazolo[3,2-a]pyridine-5-carbonitrile |
| COBI-017 | 398489-26-4 | tert-butyl 3-oxoazetidine-1-carboxylate |
| COBI-018 | 1597407-55-0 | tert-butyl 3-((3S,5R,8aS)-5-cyano-3-phenylhexahydro-2H-oxazolo[3,2-a]pyridin-5-yl)-3-hydroxyazetidine-1-carboxylate |
| COBI-019 | 1597407-56-1 | tert-butyl 3-hydroxy-3-((S)-1-((S)-2-hydroxy-1-phenylethyl)piperidin-2-yl)azetidine-1-carboxylate |
| COBI-020 | 1597407-57-2 (Freebase) | 3-((S)-1-((S)-2-hydroxy-1-phenylethyl)piperidin-2-yl)azetidin-3-ol |
| COBI-021 | 1597407-58-3 | (3-hydroxy-3-((S)-1-((S)-2-hydroxy-1-phenylethyl)piperidin-2-yl)azetidin-1-yl)(2,3,4-trifluorophenyl)methanone |
| COBI-022 | 1597407-59-4 (Freebase) | (S)-(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)(2,3,4-trifluorophenyl)methanone hydrochloride |
| Code | CAS No. | Intermediate |
|---|---|---|
| COBI-011 | 934663-52-2 | (S)-tert-butyl 2-(1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate |
| COBI-017 | 398489-26-4 | tert-butyl 3-oxoazetidine-1-carboxylate |
| COBI-023 | 109-04-6 | 2-bromopyridine |
| COBI-024 | 1415560-24-5 | tert-butyl 3-hydroxy-3-(pyridin-2-yl)azetidine-1-carboxylate |
| COBI-025 | 1415564-55-4 | - |
| COBI-026 | 1415560-00-7 | 2,2,2-trifluoro-1-(3-hydroxy-3-(pyridin-2-yl)azetidin-1-yl)ethanone hydrochloride |
| COBI-027 | 1799970-85-6 | 2,2,2-trifluoro-1-(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)ethanone hydrochloride |
| COBI-028 | 1415559-54-4 | tert-butyl 2-(3-hydroxy-1-(2,2,2-trifluoroacetyl)azetidin-3-yl)piperidine-1-carboxylate |
| COBI-029 | 934666-06-5 | tert-butyl 2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate |
| COBI-030 | 833451-96-0 | 3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl chloride |
Frequently asked questions
What are the approved indications of Cobimetinib Fumarate?
Approved indications include: 黑色素瘤.
When does the Cobimetinib Fumarate patent expire?
Based on public sources, the Cobimetinib Fumarate patent expires in 2029.
How many synthesis routes are recorded for Cobimetinib Fumarate?
3 synthesis routes are recorded; the shortest is 6 steps with 20.66 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Cobimetinib Fumarate intermediates?
1 intermediate CAS of Cobimetinib Fumarate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Cobimetinib Fumarate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24