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CAS 934663-52-2
(S)-tert-butyl 2-(1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate
Codes：COBI-011
Application context (from source-drug indications)
黑色素瘤可美替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 可美替尼Cobimetinib Fumarate | Tier C — Watch / trade | 2029 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
azetidin-3-ol hydrochloride→benzyl 3-hydroxyazetidine-1-carboxylate→benzyl 3-oxoazetidine-1-carboxylate→tert-butyl piperidine-1-carboxylate→tert-butyl 2-(1-((benzyloxy)carbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate→(R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl chloride→(S)-tert-butyl 2-(1-((benzyloxy)carbonyl)-3-(((R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl)oxy)azetidin-3-yl)piperidine-1-carboxylate→(S)-tert-butyl 2-(1-((benzyloxy)carbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate→(S)-tert-butyl 2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate→3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl fluoride→(S)-tert-butyl 2-(1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate→2,3,4-trifluorobenzoic acid→2-fluoro-4-iodoaniline→3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid→2,4,6-trifluoro-1,3,5-triazine
(S)-tert-butyl 2-(1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate→tert-butyl 3-oxoazetidine-1-carboxylate→2-bromopyridine→tert-butyl 3-hydroxy-3-(pyridin-2-yl)azetidine-1-carboxylate→COBI-025→2,2,2-trifluoro-1-(3-hydroxy-3-(pyridin-2-yl)azetidin-1-yl)ethanone hydrochloride→2,2,2-trifluoro-1-(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)ethanone hydrochloride→tert-butyl 2-(3-hydroxy-1-(2,2,2-trifluoroacetyl)azetidin-3-yl)piperidine-1-carboxylate→tert-butyl 2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate→3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl chloride
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