Inavolisib
Tier C — Watch / tradeInavolisib
Targets：PI3Kα
Brand：Itovebi
Indications (approved)：Breast cancer, Metastatic breast cancer
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| Inavolisib-001 | 591-20-8 | 3-bromophenol |
| Inavolisib-002 | 22532-62-3 | 4-bromo-2-hydroxybenzaldehyde |
| Inavolisib-003 | 1282516-66-8 | 5-bromo-2-(1H-imidazol-2-yl)phenol |
| Inavolisib-004 | 1282516-67-9 | 9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine |
| Inavolisib-005 | 1282516-68-0 | 9-bromo-2,3-diiodo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine |
| Inavolisib-006 | 1282516-69-1 | 9-bromo-2-iodo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine |
| Inavolisib-007 | 1707-77-3 | (1S,2S)-1,2-bis((R)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol |
| Inavolisib-008 | 15186-48-8Available | (R)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde |
| Inavolisib-009 | 474329-39-0 | (R)-4-(difluoromethyl)-2,2-dimethyl-1,3-dioxolane |
| Inavolisib-010 | 18162-48-6 | tert-butylchlorodimethylsilane |
| Inavolisib-011 | 2059154-95-7 | (R)-3-((tert-butyldimethylsilyl)oxy)-1,1-difluoropropan-2-ol |
| Inavolisib-012 | 925422-88-4 | (S)-(2-azido-3,3-difluoropropoxy)(tert-butyl)dimethylsilane |
| Inavolisib-013 | 2059154-98-0 | (S)-3-((tert-butyldimethylsilyl)oxy)-1,1-difluoropropan-2-amine |
| Inavolisib-014 | 2059155-02-9 | (S)-4-(difluoromethyl)oxazolidin-2-one |
| Inavolisib-015 | 68737-65-5 | (1R,2R)-N1,N2-dimethylcyclohexane-1,2-diamine |
| Inavolisib-016 | 2060571-10-8 | (S)-3-(9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-4-(difluoromethyl)oxazolidin-2-one |
| Inavolisib-017 | 56-41-7 | L-alanine |
| Code | CAS No. | Intermediate |
|---|---|---|
| Inavolisib-004 | 1282516-67-9 | 9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine |
| Inavolisib-005 | 1282516-68-0 | 9-bromo-2,3-diiodo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine |
| Inavolisib-006 | 1282516-69-1 | 9-bromo-2-iodo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine |
| Inavolisib-014 | 2059155-02-9 | (S)-4-(difluoromethyl)oxazolidin-2-one |
| Inavolisib-015 | 68737-65-5 | (1R,2R)-N1,N2-dimethylcyclohexane-1,2-diamine |
| Inavolisib-016 | 2060571-10-8 | (S)-3-(9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-4-(difluoromethyl)oxazolidin-2-one |
| Inavolisib-017 | 56-41-7 | L-alanine |
| Inavolisib-018 | 1628256-49-4 | 8-bromo-2,3-dihydrobenzo[f][1,4]oxazepin-5-aminium |
| Inavolisib-019 | 2230508-74-2 | (2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-L-alaninate |
Frequently asked questions
What are the approved indications of Inavolisib?
Approved indications include: Breast cancer, Metastatic breast cancer.
When does the Inavolisib patent expire?
No public expiry year is available for Inavolisib yet; this page updates once verified.
How many synthesis routes are recorded for Inavolisib?
2 synthesis routes are recorded; the shortest is 7 steps with 4.37 kg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Inavolisib intermediates?
1 intermediate CAS of Inavolisib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Inavolisib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-27