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CAS 474329-39-0
(R)-4-(difluoromethyl)-2,2-dimethyl-1,3-dioxolane
Codes: Inavolisib-009
Application context (from source-drug indications)
Breast cancerInavolisibMetastatic breast cancerInavolisib胰腺导管癌InavolisibType 2 diabetesInavolisibEndometrial cancerInavolisibEpithelial ovarian cancerInavolisib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Inavolisib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-bromophenol→4-bromo-2-hydroxybenzaldehyde→5-bromo-2-(1H-imidazol-2-yl)phenol→9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine→9-bromo-2,3-diiodo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine→9-bromo-2-iodo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine→(1S,2S)-1,2-bis((R)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol→(R)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde→(R)-4-(difluoromethyl)-2,2-dimethyl-1,3-dioxolane→tert-butylchlorodimethylsilane→(R)-3-((tert-butyldimethylsilyl)oxy)-1,1-difluoropropan-2-ol→(S)-(2-azido-3,3-difluoropropoxy)(tert-butyl)dimethylsilane→(S)-3-((tert-butyldimethylsilyl)oxy)-1,1-difluoropropan-2-amine→(S)-4-(difluoromethyl)oxazolidin-2-one→(1R,2R)-N1,N2-dimethylcyclohexane-1,2-diamine→(S)-3-(9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-4-(difluoromethyl)oxazolidin-2-one→L-alanine
Intermediates available on this site
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