琥珀酸普芦卡必利
Tier C — Watch / tradePrucalopride Succinate
Targets：5-HT4
Brand：Resolor、Motegrity、Resolor/Motegrity、Resotran
Indications (approved)：便秘
Regional status
Synthetic routes & intermediates5 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| PRUC-001 | 536-90-3 | 3-methoxyaniline |
| PRUC-002 | 3282-30-2 | pivaloyl chloride |
| PRUC-003 | 56619-93-3 | N-(3-methoxyphenyl)pivalamide |
| PRUC-004 | 75-21-8 | oxirane |
| PRUC-005 | 76093-72-6 | N-(2-(2-hydroxyethyl)-3-methoxyphenyl)pivalamide |
| PRUC-006 | 61090-37-7 | 2,3-dihydrobenzofuran-4-amine |
| PRUC-007 | 76093-76-0 | 5-chloro-2,3-dihydrobenzofuran-4-amine |
| PRUC-008 | 164787-52-4 | 7-bromo-5-chloro-2,3-dihydrobenzofuran-4-amine |
| PRUC-009 | 123654-26-2 | 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid |
| PRUC-010 | 179474-79-4Available | 1-(3-methoxypropyl)piperidin-4-amine |
| Code | CAS No. | Intermediate |
|---|---|---|
| PRUC-011 | 137211-64-4 | 4-amino-5-chloro-N-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide |
| PRUC-012 | 36215-07-3 | 1-chloro-3-methoxypropane |
| Code | CAS No. | Intermediate |
|---|---|---|
| PRUC-009 | 123654-26-2 | 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid |
| PRUC-010 | 179474-79-4Available | 1-(3-methoxypropyl)piperidin-4-amine |
| PRUC-013 | 65-49-6 | 4-amino-2-hydroxybenzoic acid |
| PRUC-014 | 4136-97-4 | methyl 4-amino-2-hydroxybenzoate |
| PRUC-015 | 4093-28-1 | methyl 4-acetamido-2-hydroxybenzoate |
| PRUC-016 | 24190-77-0 | methyl 4-acetamido-5-chloro-2-hydroxybenzoate |
| PRUC-017 | 232941-14-9 | methyl 4-acetamido-3-bromo-5-chloro-2-hydroxybenzoate |
| PRUC-018 | 748788-39-8Available | methyl 4-acetamido-3-bromo-2-(2-bromoethoxy)-5-chlorobenzoate |
| PRUC-019 | 143878-29-9 | methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate |
| PRUC-020 | 179474-81-8 | 4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide |
| PRUC-021 | 110-15-6 | succinic acid |
| PRUC-022 | 320589-77-3 | piperidin-4-one hydrochloride hydrate |
| PRUC-023 | 36865-41-5 | 1-bromo-3-methoxypropane |
| PRUC-024 | 16771-85-0 | 1-(3-methoxypropyl)piperidin-4-one |
| Code | CAS No. | Intermediate |
|---|---|---|
| PRUC-009 | 123654-26-2 | 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid |
| PRUC-010 | 179474-79-4Available | 1-(3-methoxypropyl)piperidin-4-amine |
| PRUC-015 | 4093-28-1 | methyl 4-acetamido-2-hydroxybenzoate |
| PRUC-019 | 143878-29-9 | methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate |
| PRUC-025 | 106-95-6Available | 3-bromoprop-1-ene |
| PRUC-026 | 91958-13-3 | methyl 4-acetamido-2-(allyloxy)benzoate |
| PRUC-027 | 110751-41-2 | methyl 4-acetamido-3-allyl-2-hydroxybenzoate |
| PRUC-028 | 202664-83-3 | methyl 4-acetamido-2-hydroxy-3-(2-oxoethyl)benzoate |
| PRUC-029 | 202664-85-5 | methyl 4-acetamido-2-hydroxy-3-(2-hydroxyethyl)benzoate |
| PRUC-030 | 149466-67-1 | methyl 4-acetamido-2,3-dihydrobenzofuran-7-carboxylate |
| Code | CAS No. | Intermediate |
|---|---|---|
| PRUC-009 | 123654-26-2 | 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid |
| PRUC-014 | 4136-97-4 | methyl 4-amino-2-hydroxybenzoate |
| PRUC-031 | 1092460-41-7 | methyl 2-hydroxy-4-(2,2,2-trifluoroacetamido)benzoate |
| PRUC-032 | 1701410-33-4 | methyl 3-(2-chloroacetyl)-2-hydroxy-4-(2,2,2-trifluoroacetamido)benzoate |
| PRUC-033 | 1701410-34-5 | methyl 3-oxo-4-(2,2,2-trifluoroacetamido)-2,3-dihydrobenzofuran-7-carboxylate |
| PRUC-034 | 1701410-35-6 | methyl 4-(2,2,2-trifluoroacetamido)-2,3-dihydrobenzofuran-7-carboxylate |
| PRUC-035 | 1701410-36-7 | methyl 5-chloro-4-(2,2,2-trifluoroacetamido)-2,3-dihydrobenzofuran-7-carboxylate |
Frequently asked questions
What are the approved indications of Prucalopride Succinate?
Approved indications include: 便秘.
When does the Prucalopride Succinate patent expire?
No public expiry year is available for Prucalopride Succinate yet; this page updates once verified.
How many synthesis routes are recorded for Prucalopride Succinate?
5 synthesis routes are recorded; the shortest is 1 steps with 1.4 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Prucalopride Succinate intermediates?
3 intermediate CAS of Prucalopride Succinate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Prucalopride Succinate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24