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CAS 320589-77-3
piperidin-4-one hydrochloride hydrate
Codes：PRUC-022
Application context (from source-drug indications)
便秘琥珀酸普芦卡必利术后并发症琥珀酸普芦卡必利肠内喂养不耐受琥珀酸普芦卡必利阿片类药物引起的便秘琥珀酸普芦卡必利疼痛琥珀酸普芦卡必利假性肠梗阻琥珀酸普芦卡必利
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 琥珀酸普芦卡必利Prucalopride Succinate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid→1-(3-methoxypropyl)piperidin-4-amine→4-amino-2-hydroxybenzoic acid→methyl 4-amino-2-hydroxybenzoate→methyl 4-acetamido-2-hydroxybenzoate→methyl 4-acetamido-5-chloro-2-hydroxybenzoate→methyl 4-acetamido-3-bromo-5-chloro-2-hydroxybenzoate→methyl 4-acetamido-3-bromo-2-(2-bromoethoxy)-5-chlorobenzoate→methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate→4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide→succinic acid→piperidin-4-one hydrochloride hydrate→1-bromo-3-methoxypropane→1-(3-methoxypropyl)piperidin-4-one
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