盐酸考尼伐坦
Tier C — Watch / tradeConivaptan Hydrochloride
Targets：V2R、AVPR1A
Brand：Vaprisol
Indications (approved)：低钠血症
Regional status
Synthetic routes & intermediates4 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| CONI-001 | 1127-74-8 | 1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one |
| CONI-002 | 122-04-3 | 4-nitrobenzoyl chloride |
| CONI-003 | 137975-89-4 | 1-(4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one |
| CONI-004 | 137976-09-1 | 1-(4-aminobenzoyl)-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one |
| CONI-005 | 947-84-2 | [1,1'-biphenyl]-2-carboxylic acid |
| CONI-006 | 168626-54-8 | N-(4-(5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide |
| CONI-007 | 124-42-5 | acetimidamide hydrochloride |
| CONI-008 | 261787-69-3 | N-(4-(4-bromo-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| CONI-007 | 124-42-5 | acetimidamide hydrochloride |
| CONI-009 | 24310-36-9 | 1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one |
| CONI-010 | 29489-04-1 | 4-bromo-1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one |
| CONI-011 | 717917-14-1 | 2-methyl-6-tosyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine |
| CONI-012 | 318237-73-9 | 2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine |
| CONI-013 | 62-23-7 | 4-nitrobenzoic acid |
| CONI-014 | 168626-71-9 | (2-methyl-4,5-dihydrobenzo[b]imidazo[4,5-d]azepin-6(1H)-yl)(4-nitrophenyl)methanone |
| CONI-015 | 195531-22-7 | (4-aminophenyl)(2-methyl-4,5-dihydrobenzo[b]imidazo[4,5-d]azepin-6(1H)-yl)methanone |
| CONI-016 | 14002-52-9 | [1,1'-biphenyl]-2-carbonyl chloride |
| Code | CAS No. | Intermediate |
|---|---|---|
| CONI-005 | 947-84-2 | [1,1'-biphenyl]-2-carboxylic acid |
| CONI-012 | 318237-73-9 | 2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine |
| CONI-016 | 14002-52-9 | [1,1'-biphenyl]-2-carbonyl chloride |
| CONI-017 | 150-13-0 | 4-aminobenzoic acid |
| CONI-018 | 168626-74-2 | 4-([1,1'-biphenyl]-2-carboxamido)benzoic acid |
| CONI-019 | 180340-05-0 | 4-([1,1'-biphenyl]-2-carboxamido)benzoyl chloride |
| Code | CAS No. | Intermediate |
|---|---|---|
| CONI-005 | 947-84-2 | [1,1'-biphenyl]-2-carboxylic acid |
| CONI-007 | 124-42-5 | acetimidamide hydrochloride |
| CONI-009 | 24310-36-9 | 1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one |
| CONI-010 | 29489-04-1 | 4-bromo-1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one |
| CONI-011 | 717917-14-1 | 2-methyl-6-tosyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine |
| CONI-017 | 150-13-0 | 4-aminobenzoic acid |
| CONI-018 | 168626-74-2 | 4-([1,1'-biphenyl]-2-carboxamido)benzoic acid |
| CONI-020 | 18820-82-1 | pyridine hydrobromide |
| CONI-021 | - | 2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine hydrate |
Frequently asked questions
What are the approved indications of Conivaptan Hydrochloride?
Approved indications include: 低钠血症.
When does the Conivaptan Hydrochloride patent expire?
No public expiry year is available for Conivaptan Hydrochloride yet; this page updates once verified.
How many synthesis routes are recorded for Conivaptan Hydrochloride?
4 synthesis routes are recorded; the shortest is 4 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Conivaptan Hydrochloride intermediates?
All intermediates in Conivaptan Hydrochloride routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Conivaptan Hydrochloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24