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CAS 168626-54-8
N-(4-(5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide
Codes:CONI-006
Application context (from source-drug indications)
低钠血症盐酸考尼伐坦急性失代偿性心力衰竭盐酸考尼伐坦心脏衰竭盐酸考尼伐坦肝脏疾病盐酸考尼伐坦创伤性脑损伤盐酸考尼伐坦肾脏疾病盐酸考尼伐坦
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 盐酸考尼伐坦Conivaptan Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→4-nitrobenzoyl chloride→1-(4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→1-(4-aminobenzoyl)-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→[1,1'-biphenyl]-2-carboxylic acid→N-(4-(5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide→acetimidamide hydrochloride→N-(4-(4-bromo-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide
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