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CAS 100427-51-8
1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl 3-oxobutanoate
Codes：Lercanidipine Hydrochloride-003
Application context (from source-drug indications)
原发性高血压缬沙坦/盐酸乐卡地平
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 缬沙坦/盐酸乐卡地平Valsartan/Lercanidipine Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-Methylene-2-oxetanone→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl 3-oxobutanoate→(3-Nitrophenyl)methanone→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl (2Z)-2-[(3-nitrophenyl)methylidene]-3-oxobutanoate→3-Amino-2-butenoic acid methyl ester→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid
1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→2,2,4-Trimethyl-6-keto-1,3-dioxin→3-Oxobutanoyl chloride→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl 3-oxobutanoate→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl (2E)-3-aminobut-2-enoate→(3-Nitrophenyl)methanone→1-Methoxybutane-1,3-dione→(Z)-2-Acetyl-3-(3-nitrophenyl)acrylic acid methyl ester
1-Methoxybutane-1,3-dione→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl 3-oxobutanoate→(3-Nitrophenyl)methanone→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl (2Z)-2-[(3-nitrophenyl)methylidene]-3-oxobutanoate→3-Amino-2-butenoic acid methyl ester→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
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