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CAS 39562-17-9

(Z)-2-Acetyl-3-(3-nitrophenyl)acrylic acid methyl ester

Codes:Lercanidipine Hydrochloride-040

Application context (from source-drug indications)

原发性高血压缬沙坦/盐酸乐卡地平

Source drugs (routes using this intermediate)

DrugTierExpiry
缬沙坦/盐酸乐卡地平Valsartan/Lercanidipine HydrochlorideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

缬沙坦/盐酸乐卡地平优化路线steps: 3total yield: /
1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→2,2,4-Trimethyl-6-keto-1,3-dioxin→3-Oxobutanoyl chloride→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl 3-oxobutanoate→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl (2E)-3-aminobut-2-enoate→(3-Nitrophenyl)methanone→1-Methoxybutane-1,3-dione→(Z)-2-Acetyl-3-(3-nitrophenyl)acrylic acid methyl ester

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