CAS 10132-07-7

2,6-dichloropyrimidin-4-amine

Codes：ETRA-021

Application context (from source-drug indications)

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Source drugs (routes using this intermediate)

Drug	Tier	Expiry
依曲韦林Etravirine	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

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依曲韦林优化路线steps: 3total yield: 379 mg

4-aminobenzonitrile→4-hydroxy-3,5-dimethylbenzonitrile→2,6-dichloropyrimidin-4-amine→5-bromo-2,6-dichloropyrimidin-4-amine→4-((6-amino-5-bromo-2-chloropyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile

依曲韦林优化路线steps: 3total yield: 442 mg

4-aminobenzonitrile→4-hydroxy-3,5-dimethylbenzonitrile→4-((4-amino-6-chloropyrimidin-2-yl)amino)benzonitrile→2,6-dichloropyrimidin-4-amine→4-((4-amino-5-bromo-6-chloropyrimidin-2-yl)amino)benzonitrile

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