依曲韦林
Tier C — Watch / tradeEtravirine
Targets：RT
Brand：Intelence
Indications (approved)：HIV感染
Regional status
Synthetic routes & intermediates6 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| ETRA-001 | 63931-21-5 | 5-bromo-2,4,6-trichloropyrimidine |
| ETRA-002 | 873-74-5Available | 4-aminobenzonitrile |
| ETRA-003 | 269055-75-6 | 4-((5-bromo-4,6-dichloropyrimidin-2-yl)amino)benzonitrile |
| ETRA-004 | 4198-90-7 | 4-hydroxy-3,5-dimethylbenzonitrile |
| ETRA-005 | 269055-76-7 | 4-((5-bromo-6-chloro-2-((4-cyanophenyl)amino)pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile |
| Code | CAS No. | Intermediate |
|---|---|---|
| ETRA-002 | 873-74-5Available | 4-aminobenzonitrile |
| ETRA-003 | 269055-75-6 | 4-((5-bromo-4,6-dichloropyrimidin-2-yl)amino)benzonitrile |
| ETRA-005 | 269055-76-7 | 4-((5-bromo-6-chloro-2-((4-cyanophenyl)amino)pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile |
| ETRA-006 | 373690-68-7 | 1-(4-cyanophenyl)guanidine hydrochloride |
| ETRA-007 | 105-53-3Available | diethyl malonate |
| ETRA-008 | 374067-80-8 | 4-((4,6-dihydroxypyrimidin-2-yl)amino)benzonitrile |
| ETRA-009 | 329187-59-9 | 4-((4,6-dichloropyrimidin-2-yl)amino)benzonitrile |
| ETRA-010 | 1398507-10-2 | sodium 4-cyano-2,6-dimethylphenolate |
| Code | CAS No. | Intermediate |
|---|---|---|
| ETRA-004 | 4198-90-7 | 4-hydroxy-3,5-dimethylbenzonitrile |
| ETRA-006 | 373690-68-7 | 1-(4-cyanophenyl)guanidine hydrochloride |
| ETRA-015 | 105-56-6Available | ethyl 2-cyanoacetate |
| ETRA-016 | 1398507-07-7 | 4-((4-amino-6-hydroxypyrimidin-2-yl)amino)benzonitrile |
| ETRA-017 | 1398507-08-8 | 4-((4-amino-6-chloropyrimidin-2-yl)amino)benzonitrile |
| ETRA-018 | 1404118-66-6 | N-(6-chloro-2-((4-cyanophenyl)amino)pyrimidin-4-yl)benzamide |
| ETRA-019 | 1404118-67-7 | N-(5-bromo-6-chloro-2-((4-cyanophenyl)amino)pyrimidin-4-yl)benzamide |
| ETRA-020 | 1404118-68-8 | N-(5-bromo-6-(4-cyano-2,6-dimethylphenoxy)-2-((4-cyanophenyl)amino)pyrimidin-4-yl)benzamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| ETRA-002 | 873-74-5Available | 4-aminobenzonitrile |
| ETRA-004 | 4198-90-7 | 4-hydroxy-3,5-dimethylbenzonitrile |
| ETRA-021 | 10132-07-7 | 2,6-dichloropyrimidin-4-amine |
| ETRA-022 | 101012-11-7 | 5-bromo-2,6-dichloropyrimidin-4-amine |
| ETRA-023 | 1415796-11-0 | 4-((6-amino-5-bromo-2-chloropyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile |
| Code | CAS No. | Intermediate |
|---|---|---|
| ETRA-002 | 873-74-5Available | 4-aminobenzonitrile |
| ETRA-004 | 4198-90-7 | 4-hydroxy-3,5-dimethylbenzonitrile |
| ETRA-017 | 1398507-08-8 | 4-((4-amino-6-chloropyrimidin-2-yl)amino)benzonitrile |
| ETRA-021 | 10132-07-7 | 2,6-dichloropyrimidin-4-amine |
| ETRA-024 | 1398507-09-9 | 4-((4-amino-5-bromo-6-chloropyrimidin-2-yl)amino)benzonitrile |
| Code | CAS No. | Intermediate |
|---|---|---|
| ETRA-002 | 873-74-5Available | 4-aminobenzonitrile |
| ETRA-004 | 4198-90-7 | 4-hydroxy-3,5-dimethylbenzonitrile |
| ETRA-011 | 3764-01-0 | 2,4,6-trichloropyrimidine |
| ETRA-012 | 1225383-63-0 | 4-((2,6-dichloropyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile |
| ETRA-013 | 1070377-34-2 | 4-((6-chloro-2-((4-cyanophenyl)amino)pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile |
| ETRA-014 | 939431-68-2 | 4-((6-amino-2-((4-cyanophenyl)amino)pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile |
Frequently asked questions
What are the approved indications of Etravirine?
Approved indications include: HIV感染.
When does the Etravirine patent expire?
No public expiry year is available for Etravirine yet; this page updates once verified.
How many synthesis routes are recorded for Etravirine?
6 synthesis routes are recorded; the shortest is 3 steps with 0.44 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Etravirine intermediates?
3 intermediate CAS of Etravirine are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Etravirine intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24