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CAS 1039631-63-4
tert-butyl (S)-3-(((R)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidine-1-carboxylate
Codes：EVOCA-004
Application context (from source-drug indications)
继发性甲状旁腺功能亢进症依伏卡塞甲状旁腺癌依伏卡塞原发性甲状旁腺功能亢进症依伏卡塞甲状旁腺功能亢进症依伏卡塞
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 依伏卡塞Evocalcet | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate→tert-butyl (R)-3-(((2-nitrophenyl)sulfonyl)oxy)pyrrolidine-1-carboxylate→(R)-1-(naphthalen-1-yl)ethan-1-amine→tert-butyl (S)-3-(((R)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidine-1-carboxylate→propan-2-ol compound with (S)-N-((R)-1-(naphthalen-1-yl)ethyl)pyrrolidin-3-amine (1:1) hydrochloride→(S)-N-((R)-1-(naphthalen-1-yl)ethyl)pyrrolidin-3-amine→ethyl 2-(4-bromophenyl)acetate→ethyl 2-(4-((S)-3-(((R)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)phenyl)acetate hydrochloride→2-(4-((S)-3-(((R)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)phenyl)acetic acid
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