CAS 108-86-1

bromobenzeneBromanylbenzene

Codes：GLYC-018、(VI)70353-2-a

Application context (from source-drug indications)

哮喘布地奈德/富马酸福莫特/格隆溴铵慢性阻塞性肺疾病布地奈德/富马酸福莫特/格隆溴铵细菌感染和真菌感染倍他米松/克霉唑/硫酸庆大霉素慢性阻塞性肺疾病马来酸茚达特罗/格隆溴铵

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
布地奈德/富马酸福莫特/格隆溴铵Budesonide/Formoterol fumarate/Glycopyrronium Bromide	Tier B — Position early	-
倍他米松/克霉唑/硫酸庆大霉素Betamethasone/Clotrimazole/Gentamicin Sulfate	Tier C — Watch / trade	-
马来酸茚达特罗/格隆溴铵Indacaterol Maleate/Glycopyrronium Bromide	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

布地奈德/富马酸福莫特/格隆溴铵优化路线steps: 3total yield: /

1-methylpyrrolidin-3-ol→1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate→2-cyclopentyl-2-oxoacetic acid→1-methylpyrrolidin-3-yl 2-cyclopentyl-2-oxoacetate→bromobenzene

倍他米松/克霉唑/硫酸庆大霉素优化路线steps: 6total yield: /

(2-Chlorophenyl)(iodo)magnesium→(14C)-2-Chlorobenzoic acid→(14C)-2-Chlorobenzoyl chloride→Benzene→(14C)-2-Chlorobenzophenone→Bromanylbenzene→(14C)-(2-Chlorophenyl)diphenylmethanol→(14C)-1-(2-Chlorophenyl)-1,1-diphenylmethyl chloride→1,3-Diaza-2,4-cyclopentadiene→(14C)-1-[1-(2-Chlorophenyl)-1,1-diphenylmethyl]-1H-imidazole

马来酸茚达特罗/格隆溴铵优化路线steps: 3total yield: /

1-methylpyrrolidin-3-ol→1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate→2-cyclopentyl-2-oxoacetic acid→1-methylpyrrolidin-3-yl 2-cyclopentyl-2-oxoacetate→bromobenzene

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