CAS 288-32-4

1H-imidazole

Codes：PRET-008、DIQU-003

Application context (from source-drug indications)

结核分枝杆菌感染普托马尼耐多药肺结核普托马尼肺结核普托马尼广泛耐药结核普托马尼肾功能不全普托马尼干眼症地夸磷索钠干眼综合征地夸磷索钠干燥性角结膜炎地夸磷索钠

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
普托马尼Pretomanid	Tier C — Watch / trade	-
地夸磷索钠Diquafosol Tetrasodium	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

普托马尼优化路线steps: 8total yield: 13.33 g (Pretomanid)

2,4-dinitro-1H-imidazole→(6S)-2-nitro-6-((tetrahydro-2H-pyran-2-yl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine→(S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol→1-(bromomethyl)-4-(trifluoromethoxy)benzene→1H-imidazole→4-nitro-1H-imidazole→1,4-dinitro-1H-imidazole→(S)-oxiran-2-ylmethyl butyrate→(S)-3-(2,4-dinitro-1H-imidazol-1-yl)-2-hydroxypropyl butyrate→(2S)-3-(2,4-dinitro-1H-imidazol-1-yl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propyl butyrate

地夸磷索钠优化路线steps: 2total yield: /

((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen diphosphate→1H-imidazole→(1H-imidazol-1-yl)phosphonic (((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphoric) anhydride

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