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CAS 109882-25-9

methyl 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate

Codes:BENDAM-010

Application context (from source-drug indications)

B-细胞淋巴瘤盐酸苯达莫司汀非霍奇金淋巴瘤盐酸苯达莫司汀慢性淋巴细胞白血病盐酸苯达莫司汀套细胞淋巴瘤盐酸苯达莫司汀淋巴瘤盐酸苯达莫司汀多发性骨髓瘤盐酸苯达莫司汀

Source drugs (routes using this intermediate)

DrugTierExpiry
盐酸苯达莫司汀Bendamustine HydrochlorideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

盐酸苯达莫司汀工艺路线steps: 5total yield: 626 g
2,4-dinitroaniline→methyl 5-chloro-5-oxopentanoate→methyl 5-((2,4-dinitrophenyl)amino)-5-oxopentanoate→methyl 5-((2,4-dinitrophenyl)(methyl)amino)-5-oxopentanoate→methyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate hydrochloride→methyl 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate

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