盐酸苯达莫司汀
Tier C — Watch / tradeBendamustine Hydrochloride
Targets：DNA
Brand：Treanda、Bendeka、Levact、Treakisym、Ribomustin、Benda、Symbenda、Innomustine、Bentaman、Cytostasan、存达
Indications (approved)：B-细胞淋巴瘤、非霍奇金淋巴瘤、慢性淋巴细胞白血病、套细胞淋巴瘤
Regional status
Synthetic routes & intermediates4 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| BENDAM-001 | 1313020-26-6 | isopropyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate |
| BENDAM-002 | 107-07-3 | 2-chloroethan-1-ol |
| BENDAM-003 | 1313020-24-4 | isopropyl 4-(5-(bis(2-hydroxyethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate |
| BENDAM-004 | 1313020-25-5 | isopropyl 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate |
| Bendamustine Hydrochloride | 3543-75-7 | - |
| Code | CAS No. | Intermediate |
|---|---|---|
| BENDAM-002 | 107-07-3 | 2-chloroethan-1-ol |
| BENDAM-011 | 6283-25-6 | 2-chloro-5-nitroaniline |
| BENDAM-012 | 108-55-4 | dihydro-2H-pyran-2,6(3H)-dione |
| BENDAM-013 | 196943-45-0 | 5-((2-chloro-5-nitrophenyl)amino)-5-oxopentanoic acid |
| BENDAM-014 | 91644-13-2 | 5-((2-(methylamino)-5-nitrophenyl)amino)-5-oxopentanoic acid |
| BENDAM-015 | 3543-72-4 | ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate |
| BENDAM-016 | 3543-73-5 | ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate |
| BENDAM-017 | 3543-74-6 | ethyl 4-(5-(bis(2-hydroxyethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate |
| Code | CAS No. | Intermediate |
|---|---|---|
| BENDAM-012 | 108-55-4 | dihydro-2H-pyran-2,6(3H)-dione |
| BENDAM-018 | 29705-38-2 | 2,2'-((4-fluoro-3-nitrophenyl)azanediyl)bis(ethan-1-ol) |
| BENDAM-019 | 2784-94-3 | 2,2'-((4-(methylamino)-3-nitrophenyl)azanediyl)bis(ethan-1-ol) |
| BENDAM-020 | - | 2,2'-((3-amino-4-(methylamino)phenyl)azanediyl)bis(ethan-1-ol) |
| BENDAM-021 | 1464999-05-0 | 4-(5-(bis(2-hydroxyethyl)amino)-2-hydroxy-1-methyl-2,3-dihydro-1H-benzo[d]imidazol-2-yl)butanoic acid |
| BENDAM-022 | 109882-31-7 | methyl 4-(5-(bis(2-hydroxyethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate |
| Code | CAS No. | Intermediate |
|---|---|---|
| BENDAM-005 | 97-02-9 | 2,4-dinitroaniline |
| BENDAM-006 | 1501-26-4 | methyl 5-chloro-5-oxopentanoate |
| BENDAM-007 | 1221157-09-0 | methyl 5-((2,4-dinitrophenyl)amino)-5-oxopentanoate |
| BENDAM-008 | - | methyl 5-((2,4-dinitrophenyl)(methyl)amino)-5-oxopentanoate |
| BENDAM-009 | 1221157-11-4 | methyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate hydrochloride |
| BENDAM-010 | 109882-25-9 | methyl 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate |
Frequently asked questions
What are the approved indications of Bendamustine Hydrochloride?
Approved indications include: B-细胞淋巴瘤, 非霍奇金淋巴瘤, 慢性淋巴细胞白血病, 套细胞淋巴瘤.
When does the Bendamustine Hydrochloride patent expire?
No public expiry year is available for Bendamustine Hydrochloride yet; this page updates once verified.
How many synthesis routes are recorded for Bendamustine Hydrochloride?
4 synthesis routes are recorded; the shortest is 3 steps with 2.2 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Bendamustine Hydrochloride intermediates?
All intermediates in Bendamustine Hydrochloride routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Bendamustine Hydrochloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24