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CAS 110267-78-2
(1S,5S)-7,14-dihydroxy-3-methyl-5-(2-methyl-1,3-dioxolan-2-yl)-5,6-dihydro-1H-1,5-methanoanthra[2,3-f][1,3]oxazocine-8,13-dione
Codes: AMRU-009
Application context (from source-drug indications)
Non-small cell lung cancerAmrubicin HydrochlorideSmall cell lung cancerAmrubicin HydrochlorideLung cancerAmrubicin HydrochlorideSarcomaAmrubicin HydrochlorideMetastatic breast cancerAmrubicin HydrochlorideSolid tumourAmrubicin Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Amrubicin Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
5,8-dimethoxy-3,4-dihydronaphthalen-2(1H)-one→2-amino-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid→methyl (R)-2-amino-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate→(R)-1-(2-amino-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-yl)ethan-1-one→(R)-N-(2-acetyl-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide→isobenzofuran-1,3-dione→(R)-N-(2-acetyl-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)acetamide→(R)-N-(5,12-dihydroxy-2-(2-methyl-1,3-dioxolan-2-yl)-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)acetamide→(1S,5S)-7,14-dihydroxy-3-methyl-5-(2-methyl-1,3-dioxolan-2-yl)-5,6-dihydro-1H-1,5-methanoanthra[2,3-f][1,3]oxazocine-8,13-dione→(7S,9S)-9-acetyl-9-amino-6,7,11-trihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione→AMRU-011→AMRU-012
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