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CAS 1110767-89-9
(E)-3,5-dichloro-4-(3-ethoxy-2-methyl-3-oxoprop-1-en-1-yl)benzoic acid
Codes：LUSU-009
Application context (from source-drug indications)
血小板减少芦曲泊帕
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 芦曲泊帕Lusutrombopag | Tier C — Watch / trade | 2031 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(3-bromo-2-methoxyphenyl)ethanone→(S)-1-(3-bromo-2-methoxyphenyl)ethanol→1-iodohexane→(S)-1-bromo-3-(1-(hexyloxy)ethyl)-2-methoxybenzene→2-chloro-N-methoxy-N-methylacetamide→(S)-2-chloro-1-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)ethanone→thiourea→(S)-4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-amine→(E)-3,5-dichloro-4-(3-ethoxy-2-methyl-3-oxoprop-1-en-1-yl)benzoic acid→(S,E)-ethyl 3-(2,6-dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylate→3,5-dichloro-4-formylbenzoic acid→ethyl 2-(diethoxyphosphoryl)propanoate
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