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CAS 62-56-6
thioureaSulfoureaAminothiocarboxamide
Codes：TICA-041、AVAN-026、AVAT-003、LUSU-007、FEBU-014、Cefoselis Sulfate-033、S-pantoprazole sodium-055
Application context (from source-drug indications)
中风替格瑞洛急性冠脉综合征替格瑞洛心肌梗塞替格瑞洛外周血管疾病替格瑞洛勃起功能障碍阿伐那非血小板减少马来酸阿伐曲泊帕特发性血小板减少性紫癜马来酸阿伐曲泊帕肝脏疾病马来酸阿伐曲泊帕血小板减少芦曲泊帕高尿酸血症非布司他痛风非布司他颅内出血非布司他溃疡性结肠炎非布司他慢性肾功能不全非布司他疼痛非布司他细菌感染硫酸头孢噻利胃食管反流病（S）-泮托拉唑钠消化性溃疡（S）-泮托拉唑钠出血（S）-泮托拉唑钠创伤和损伤（S）-泮托拉唑钠昏迷（S）-泮托拉唑钠吸入性肺炎（S）-泮托拉唑钠
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 替格瑞洛Ticagrelor | Tier B — Position early | 2029 |
| 阿伐那非Avanafil | Tier C — Watch / trade | 2028 |
| 马来酸阿伐曲泊帕Avatrombopag Maleate | Tier C — Watch / trade | 2030 |
| 芦曲泊帕Lusutrombopag | Tier C — Watch / trade | 2031 |
| 非布司他Febuxostat | Tier C — Watch / trade | - |
| 硫酸头孢噻利Cefoselis Sulfate | Tier C — Watch / trade | - |
| （S）-泮托拉唑钠S-pantoprazole sodium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4,6-dichloro-2-(propylthio)pyrimidin-5-amine→diethyl 2-acetamidomalonate→thiourea→sodium 5-acetamido-4,6-dihydroxypyrimidine-2-thiolate→N-(4,6-dihydroxy-2-mercaptopyrimidin-5-yl)acetamide→1-bromopropane→N-(4,6-dihydroxy-2-(propylthio)pyrimidin-5-yl)acetamide→5-amino-2-(propylthio)pyrimidine-4,6-diol hydrochloride
diethyl 2-(ethoxymethylene)malonate→(3-chloro-4-methoxyphenyl)methanamine hydrochloride→(S)-pyrrolidin-2-ylmethanol→pyrimidin-2-ylmethanamine→thiourea→AVAN-027→AVAN-028→AVAN-029→AVAN-030→AVAN-031→AVAN-032→AVAN-033
1-(4-chlorothiophen-2-yl)ethanone→2-bromo-1-(4-chlorothiophen-2-yl)ethanone→thiourea→4-(4-chlorothiophen-2-yl)thiazol-2-amine→1-cyclohexylpiperazine→4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine→5,6-dichloronicotinic acid→5,6-dichloro-N-(4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)nicotinamide→ethyl piperidine-4-carboxylate→ethyl 1-(3-chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylate→maleic acid
1-(3-bromo-2-methoxyphenyl)ethanone→(S)-1-(3-bromo-2-methoxyphenyl)ethanol→1-iodohexane→(S)-1-bromo-3-(1-(hexyloxy)ethyl)-2-methoxybenzene→2-chloro-N-methoxy-N-methylacetamide→(S)-2-chloro-1-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)ethanone→thiourea→(S)-4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-amine→(E)-3,5-dichloro-4-(3-ethoxy-2-methyl-3-oxoprop-1-en-1-yl)benzoic acid→(S,E)-ethyl 3-(2,6-dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylate→3,5-dichloro-4-formylbenzoic acid→ethyl 2-(diethoxyphosphoryl)propanoate
ethyl 2-chloro-3-oxobutanoate→1-bromo-2-methylpropane→ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate→5-bromo-2-hydroxybenzaldehyde→5-bromo-2-isobutoxybenzaldehyde→5-bromo-2-isobutoxybenzonitrile→(3-cyano-4-isobutoxyphenyl)boronic acid→ethyl 2-bromo-4-methylthiazole-5-carboxylate→thiourea→ethyl 2-amino-4-methylthiazole-5-carboxylate
4-Chloro-2(Z)-(methoxyimino)-3-oxobutyric acid→5-amino-2-{[(6R,7R)-7-amino-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1-(2-hydroxyethyl)-1H-pyrazol-2-ium→3-amino-1-{[(6R,7R)-2-carboxylato-7-[(2Z)-4-chloro-2-(methoxyimino)-3-oxobutanamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-2-(2-hydroxyethyl)-2H-pyrazol-1-ium→Sulfourea→(6R,7R)-3-[[5-Amino-1-(2-hydroxyethyl)-1H-pyrazol-2-ium-2-yl]methyl]-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
2-(Chloromethyl)-3,4-dimethoxypyridine hydrogen chloride→Aminothiocarboxamide→(3,4-Dimethoxypyridin-2-yl)methyl hydrosulfide→Chloridocarbonic acid ethyl ester→Ethyl (3,4-dimethoxy-2-pyridyl)methylsulfanylformate→1,2-Diamino-4-(difluoromethoxy)benzene→5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfanyl)-1H-benzimidazole→5-(Difluoromethoxy)-2-(3,4-dimethoxypyridin-2-ylmethylsulfinyl)-1H-benzimidazole
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