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CAS 113020-21-6
1-(methoxycarbonyl)cyclopropane-1-carboxylic acid
Codes：DCC-2618-007、ANLO-002
Application context (from source-drug indications)
胃肠道间质瘤瑞派替尼肺泡软组织肉瘤盐酸安罗替尼肝细胞癌盐酸安罗替尼子宫内膜癌盐酸安罗替尼甲状腺瘤盐酸安罗替尼甲状腺髓样癌盐酸安罗替尼小细胞肺癌盐酸安罗替尼
Source drugs (routes using this intermediate)
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
N-(2,5-difluoro-4-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)phenyl)-N-phenylcyclopropane-1,1-dicarboxamide hydrochloride→2-chloropyridin-4-ol→1,2,4-trifluoro-5-nitrobenzene→2-chloro-4-(2,5-difluoro-4-nitrophenoxy)pyridine→4-((2-chloropyridin-4-yl)oxy)-2,5-difluoroaniline→1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole→2,5-difluoro-4-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)aniline→1-(methoxycarbonyl)cyclopropane-1-carboxylic acid→methyl 1-((2,5-difluoro-4-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylate→lithium 1-((2,5-difluoro-4-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylate→N-(2,5-difluoro-4-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)phenyl)-N-phenylcyclopropane-1,1-dicarboxamide
dimethyl cyclopropane-1,1-dicarboxylate→1-(methoxycarbonyl)cyclopropane-1-carboxylic acid→methyl 1-(hydroxymethyl)cyclopropane-1-carboxylate→1-(4-hydroxy-3-methoxyphenyl)ethan-1-one→methyl 1-((4-acetyl-2-methoxyphenoxy)methyl)cyclopropane-1-carboxylate→methyl 1-((4-acetyl-2-methoxy-5-nitrophenoxy)methyl)cyclopropane-1-carboxylate→methyl 1-((4-acetyl-5-amino-2-methoxyphenoxy)methyl)cyclopropane-1-carboxylate→methyl 1-(((4-hydroxy-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropane-1-carboxylate→methyl 1-(((4-chloro-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropane-1-carboxylate→4-fluoro-2-methyl-1H-indol-5-ol→methyl 1-(((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropane-1-carboxylate→1-(((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropane-1-carboxylic acid→benzyl (1-(((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropyl)carbamate
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