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CAS 114772-38-2
methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate
Codes：TELM-019
Application context (from source-drug indications)
高血压替米沙坦/苯磺酸氨氯地平/氢氯噻嗪高血压瑞舒伐他汀钙/替米沙坦高脂血症瑞舒伐他汀钙/替米沙坦高血压苯磺酸氨氯地平/替米沙坦
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 替米沙坦/苯磺酸氨氯地平/氢氯噻嗪Telmisartan/Amlodipine Besylate/Hydrochlorothiazide | Tier C — Watch / trade | - |
| 瑞舒伐他汀钙/替米沙坦Rosuvastatin Calcium/Telmisartan | Tier C — Watch / trade | - |
| 苯磺酸氨氯地平/替米沙坦Amlodipine Besylate/Telmisartan | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→o-cresol→4-hydroxy-3-methylbenzaldehyde→4-hydroxy-3-methyl-5-nitrobenzaldehyde→4-methoxy-3-methyl-5-nitrobenzaldehyde→benzene-1,2-diamine→2-(4-methoxy-3-methyl-5-nitrophenyl)-1-methyl-1H-benzo[d]imidazole→2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6-nitroaniline→methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→methyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→4-bromo-2-methyl-6-nitroaniline→butyraldehyde→6-bromo-4-methyl-2-propyl-1H-benzo[d]imidazole→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→TELM-025→TELM-026→2-bromo-1-methyl-1H-benzo[d]imidazole
1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→o-cresol→4-hydroxy-3-methylbenzaldehyde→4-hydroxy-3-methyl-5-nitrobenzaldehyde→4-methoxy-3-methyl-5-nitrobenzaldehyde→benzene-1,2-diamine→2-(4-methoxy-3-methyl-5-nitrophenyl)-1-methyl-1H-benzo[d]imidazole→2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6-nitroaniline→methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→methyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→4-bromo-2-methyl-6-nitroaniline→butyraldehyde→6-bromo-4-methyl-2-propyl-1H-benzo[d]imidazole→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→TELM-025→TELM-026→2-bromo-1-methyl-1H-benzo[d]imidazole
1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→o-cresol→4-hydroxy-3-methylbenzaldehyde→4-hydroxy-3-methyl-5-nitrobenzaldehyde→4-methoxy-3-methyl-5-nitrobenzaldehyde→benzene-1,2-diamine→2-(4-methoxy-3-methyl-5-nitrophenyl)-1-methyl-1H-benzo[d]imidazole→2-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6-nitroaniline→methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→methyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→4-bromo-2-methyl-6-nitroaniline→butyraldehyde→6-bromo-4-methyl-2-propyl-1H-benzo[d]imidazole→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→TELM-025→TELM-026→2-bromo-1-methyl-1H-benzo[d]imidazole
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