Unibest 优贝德
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CAS 1644483-28-2

Codes：TELM-025、TELM-026

Application context (from source-drug indications)

高血压替米沙坦/苯磺酸氨氯地平/氢氯噻嗪高血压瑞舒伐他汀钙/替米沙坦高脂血症瑞舒伐他汀钙/替米沙坦高血压苯磺酸氨氯地平/替米沙坦

Source drugs (routes using this intermediate)

DrugTierExpiry
替米沙坦/苯磺酸氨氯地平/氢氯噻嗪Telmisartan/Amlodipine Besylate/HydrochlorothiazideTier C — Watch / trade-
瑞舒伐他汀钙/替米沙坦Rosuvastatin Calcium/TelmisartanTier C — Watch / trade-
苯磺酸氨氯地平/替米沙坦Amlodipine Besylate/TelmisartanTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

替米沙坦/苯磺酸氨氯地平/氢氯噻嗪优化路线steps: 4total yield: 86.7 mg
methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→4-bromo-2-methyl-6-nitroaniline→butyraldehyde→6-bromo-4-methyl-2-propyl-1H-benzo[d]imidazole→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→TELM-025→TELM-026→2-bromo-1-methyl-1H-benzo[d]imidazole
瑞舒伐他汀钙/替米沙坦优化路线steps: 4total yield: 86.7 mg
methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→4-bromo-2-methyl-6-nitroaniline→butyraldehyde→6-bromo-4-methyl-2-propyl-1H-benzo[d]imidazole→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→TELM-025→TELM-026→2-bromo-1-methyl-1H-benzo[d]imidazole
苯磺酸氨氯地平/替米沙坦优化路线steps: 4total yield: 86.7 mg
methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→4-bromo-2-methyl-6-nitroaniline→butyraldehyde→6-bromo-4-methyl-2-propyl-1H-benzo[d]imidazole→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→TELM-025→TELM-026→2-bromo-1-methyl-1H-benzo[d]imidazole

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