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CAS 1182822-31-6
5-amino-2,4-di-tert-butylphenyl methyl carbonate
Codes：IVAC-020
Application context (from source-drug indications)
囊性纤维化艾伐卡托慢性支气管炎艾伐卡托慢性阻塞性肺疾病艾伐卡托鼻窦炎艾伐卡托
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 艾伐卡托Ivacaftor | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-nitrobenzoyl chloride→diethyl 2-(2-nitrobenzoyl)malonate→ethyl 3-(2-nitrophenyl)-3-oxopropanoate→5-amino-2,4-di-tert-butylphenyl methyl carbonate→2,4-di-tert-butyl-5-(3-(2-nitrophenyl)-3-oxopropanamido)phenyl methyl carbonate→2,4-di-tert-butyl-5-(3-(dimethylamino)-2-(2-nitrobenzoyl)acrylamido)phenyl methyl carbonate→2,4-di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl methyl carbonate
5-amino-2,4-di-tert-butylphenyl methyl carbonate→2,4-di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl methyl carbonate→methyl (E)-3-methoxyacrylate→(E)-3-methoxyacryloyl chloride→(E)-2,4-di-tert-butyl-5-(3-methoxyacrylamido)phenyl methyl carbonate→(E)-2,4-di-tert-butyl-5-(3-morpholinoacrylamido)phenyl methyl carbonate→methyl 2-aminobenzoate→methyl (E)-2-((3-((2,4-di-tert-butyl-5-((methoxycarbonyl)oxy)phenyl)amino)-3-oxoprop-1-en-1-yl)amino)benzoate
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